TNFRSF11A Antibodies

Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis.

Involved in the regulation of interactions between T-cells and dendritic cells.

.

Gene Information

Human
Gene Name:	TNFRSF11A
Uniprot:	Q9Y6Q6
Entrez:	8792

Family

Belongs to:
No superfamily

Alternative Names

CD265 antigen; CD265; FEO; loss of heterozygosity, 18, chromosomal region 1; ODFR; ODFROSTS; OFE; OPTB7; Osteoclast differentiation factor receptor; PDB2; RANK; RANKLOH18CR1; Receptor activator of NF-KB; receptor activator of nuclear factor-kappa B; TNFRSF11A; TRANCE R; TRANCER; tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, activator of NFKB; tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Molecular Weight

Mass (kDA):
66.034 kDA

Genomic Context

Human
Location:	18q21.33
Sequence:	18; NC_000018.10 (62325287..62391288)

Tissue Specificity

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform RANK-e5a]: Cell membrane; Single-pass type I membrane protein.

Diseases

• Osteoporosis
• Osteopenia
• Bone Diseases
• Arthritis
• Osteolysis
• Rheumatoid Arthritis
• Malignant Neoplasms
• Neoplasms
• Inflammation
• Neoplasm Metastasis
• Bone Neoplasms
• Multiple Myeloma
• Metastatic Malignant Neoplasm To The Bone

• Albers-schonberg Disease
• Trance State
• Osteitis Deformans
• Fracture
• Metabolic Bone Disorder
• Osteoporosis, Postmenopausal
• Periodontitis

Interacting Proteins

• EGFR
• TNFSF11
• TRAF2

Pathways

• Bone Resorption
• Osteoclast Differentiation
• Bone Remodeling
• Pathogenesis
• Secretion
• Osteoclast Development
• Localization
• Cell Proliferation
• Osteoblast Differentiation
• Cell Differentiation
• Immune Response
• Cell Growth
• Cytokine Production

• Cell Death
• Regulation Of Bone Resorption
• Menopause
• Regulation Of Osteoclast Differentiation
• Bone Development
• Cell Activation
• Cell Migration

PTMs

• Phosphorylation
• Cleavage
• Methylation
• Ubiquitination
• Dephosphorylation
• Glycosylation

• Geranylgeranylation
• Prenylation
• Demethylation
• Carboxylation
• Farnesylation
• Acetylation

Research Areas

• Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFRSF11A

Best Uses Of The TNFRSF11A Marker

TNFRSF11A A protein, which is that is present in a wide range of human tissues is a protein. It is used to monitor the growth of cancer cells and to assess the process of aging. It is also vital in the treatment and detection of cancer cells. To learn more, read our explanation of the TNFRSF11A marker. We also explore its potential applications and the areas of focus.

TNFRSF11A Marker

The TNFRSF11A gene is a member of the TNF receptor superfamily. It regulates inflammation. A number of genes are involved in the development of macrophages, lymphoid nodes, B cells, and lymph nodes. These genes include adenosine deaminase 2, TNF receptor superfamily member 11a, adhesion G protein-coupled receptor E2, laccase domain-containing 1 (PLA-SEA), and tRNA nucleotyltransferase.

Applications

This study revealed several uses of the TNFRSF11A cancer marker. In addition to its function in the development of thymic tissue and immune system function, this marker also appears to affect T cell gene expression. A decrease in CNA level may cause an increase in TNFRSF11A expression. The gene could be crucial for specific interactions with T cells. To further investigate the possibilities the study sought to examine the expression of the TNFRSF11A gene.

RNAscope is a quantitative method to determine the expression of genes on archives FFPE material. Similar to immunohistochemistry, RNAscope has been used to quantify mRNA expression of candidate prognostic markers and determine their association with clinicopathological features. RNAscope(r), was used to measure intra-tumour levels of GFI and the TNFRSF11A mRNA.

The TCGA study also showed that the mRNA expressions of TNFRSF11A, GFI1 and TNFRSF11A are linked to CNA status. These associations are consistent with the results of cBioPortal. However the TCGA study revealed a link between the mRNA levels of TNFRSF11A and the copy number of GFI1. Moreover, copy number loss could explain the lower expression of TNFRSF11A in some TCGA cancers.

Kruppel-like Factor 5 (KLF5) is a protein involved in inflammation and cancer. It interacts with TNFRSF11a. KLF5 promotes the invasion, migration and proliferation of cervical cancer cells. KLF5 expression has also been found to influence the expression of the TNFRSF11a gene. Additionally, TNFRSF11a is found in cancer cells and inhibits KLF5 activity. This enhances the tumorigenicity of the liver as well as its metastatic potential.

TNFRSF11A was also associated with intestinal epithelial differentiate. The gene GFI1 was previously linked to the epithelial cells of the intestine to differentiate. TNFRSF11A is part of the TNF receptor superfamily. It plays a significant role in bone remodelling as well as immunity. Its reduced copy number (18q deletion) and reduced expression were important factors in the selection of this gene. It is important to keep in mind that even though the TNFRSF11A expression of mRNAs has not yet been verified in clinical trials, it has been linked with specific molecular subtypes. Further research is needed to determine the significance of this gene in the process of causing colorectal cancer.

Targets

Boster Bio specializes in the development of picogram sensitivity ELISA kits and IHC-optimized polyclonal antibody. They have over 12,000 antibodies which have been tested for use in IHC, WB, flow, and Western blot. The antibodies are tested against 250 different tissues as well as untransfected cells. The products are engineered to have the highest sensitivity and affinity.

The TNFRSF11A marker can identify a variety of cells that are targeted. It regulates a variety of cellular functions. This includes the metabolism and cellular cleanup. It can also influence allergic reactions and innate immunity. To learn more about the TNFRSF11A protein go to the Boster Bio website. It's an excellent resource for research.

The TNFRSF11A protein is known to modulate several cytokine pathways. GM-CSF may target the TNFRSF11A protein. CCL2 and GM-CSF were used in a study to determine the impact of CCL2 on the production of cytokine by neutrophils. LPS alone and CCL2 together produced a high expression of cytokine-dependent inflammatory markers.