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Ticam2 Antibodies
AND Ticam2 ELISA kits, Ticam2 Proteins
Many biological assays use antibodies to detect Ticam2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ticam2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ticam2 antibodies...
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Ticam2 Infographic by Boster Bio
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Ticam2 Overview
Facts about TIR domain-containing adapter molecule 2.
TIR domain-containing adapter molecule 2 (Ticam2)
Functions as sorting adapter in LPS-TLR4 signaling to modulate the MYD88-independent pathway through the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 sign to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4.
May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKBnonetheless, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Ticam2 |
| Uniprot: | Q8BJQ4 |
| Entrez: | 225471 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MGC129876; MGC129877; Putative NF-kappa-B-activating protein 502; TICAM2; TICAM-2TIR domain-containing adapter molecule 2; TIRAP3; TIRP; TIRPcytoplasmic adaptor; toll/interleukin-1 receptor (TIR) domain-containing adapter protein; Toll/interleukin-1 receptor domain-containing protein; toll-like receptor adaptor molecule 2; Toll-like receptor adaptor protein 3; TRAM; TRAMNF-kappa-B-activating protein 502; Trif; TRIF-related adapter molecule; TRIF-related adaptor molecule
Molecular Weight
Mass (kDA):
26.362 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 18|18 C |
| Sequence: | 18; |
Diseases
- Inflammation
- Communicable Diseases
- Innate Immune Response
- Infective Disorder
- Liver Carcinoma
- Hepatitis, Chronic
- Hepatitis C, Chronic
- Hepatitis B
- Myeloid Leukemia, Chronic
- Malignant Neoplasms
- Bacterial Infections
- Brain Injuries
- Vaccinia
Pathways
- Immune Response
- Cytokine Production
- Secretion
- Innate Immune Response
- Toll-like Receptor Signaling Pathway
- Reverse Transcription
- Detection Of Lipopolysaccharide
- Cytokine Secretion
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Ticam2
bosterbio.com/bosterbio-gene-info-cards/Ticam2
References
PMID: 12721283 by Bin L.-H., et al. TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling.
PMID: 14519765 by Oshiumi H., et al. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon- beta.
1 Publications of Boster Ticam2 Antibodies & ELISA Kits
- PubMed ID: 32417325, Wang F,Ji S,Wang M,Liu L,Li Q,Jiang F,Cen J,Ji B.HMGB1 promoted P-glycoprotein a...
*More publications can be found for each product on its corresponding product page