Thrombomodulin Antibodies

Thrombomodulin (THBD)

Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca).

Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. .

Gene Information

Human
Gene Name:	THBD
Uniprot:	P07204
Entrez:	7056

Family

Belongs to:
No superfamily

Alternative Names

BDCA3; BDCA-3; CD141 antigen; CD141; Fetomodulin; THBD; THRM; Thrombomodulin; TM

Molecular Weight

Mass (kDA):
60.329 kDA

Genomic Context

Human
Location:	20p11.21
Sequence:	20; NC_000020.11 (23045633..23049672, complement)

Tissue Specificity

Endothelial cells are unique in synthesizing thrombomodulin.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Malignant Neoplasms
• Inflammation
• Thrombosis
• Neoplasms
• Disseminated Intravascular Coagulation
• Tissue Adhesions
• Hemolytic-uremic Syndrome
• Von Willebrand Disease
• Atherosclerosis
• Coronary Artery Disease
• Carcinoma
• Uremia Syndrome
• Cerebrovascular Accident

• Kidney Failure
• Hemorrhage
• Microangiopathic Hemolytic Anemia
• Anemia
• Thrombophilia
• Blood Coagulation Disorders
• Anemia, Hemolytic

Interacting Proteins

• F2

Pathways

• Coagulation
• Pathogenesis
• Methylation
• Blood Coagulation
• Dna Methylation
• Inflammatory Response
• Hemostasis
• Angiogenesis
• Fibrinolysis
• Cell Activation
• Complement Activation
• Transdifferentiation
• Cell Proliferation

• Localization
• Demethylation
• Cell Adhesion
• Gene Silencing
• Dna Hypermethylation
• Tube Formation
• Cell Cycle Arrest

PTMs

• Methylation
• Demethylation

• Cleavage
• Phosphorylation

• Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/THBD

Boster Bio Review - THBD Marker and Multichannel Pipette

This article will look at the THBD Marker and Multichannel Pipette of Boster Bio, as well as provide additional information about Steven Boster's past. We'll also go over the possible uses for the company's THBD Marker and its THBD Reagent. After reading our Boster Bio review you'll be able to make your decision.

Boster Bio's THBD Marker

THBD, short for transhistidine-binding DNA, is a new protein that is now available from Boster Bio. This protein has been validated by Boster Bio for IHC, WB and ELISA. It is also Flow Cytometry compatible, making it a valuable tool for biomedical research. Steven Xia, a well-known histologist, founded the company in 1993. Boster Bio has more than 28,000 publications that have cited their products. Boster Bio actively expands its product lines each month and strives to offer top-quality service and a premium product.

Boster Bio's Antiglucophorin A CD235a Monoclonal Antibody

The monoclonal antibody for the THBD marker consists of a minimal fragment that has an entire antigen-recognition as well as a -binding site. This antibody is made up of two heavy chains and a light chain, each of which has a variable domain. Six hypervariable regions constitute the antigen-binding domain. Three of these regions have been preserved in human antibodies. These regions provide specificity for binding. The heavy chain also has a V gene section.

In addition to the antigen-binding region, the heavy chain of this monoclonal antigen has two regions. The first is the antigen binding zone, and the second is the CH2 domain. The heavy chain/light chain combination can bind to antigens in two ways, either separately or in pairs.

These molecules are created through co-expression of the heavy chain polypeptide of a human and an IgG antibody. The three molecules are then purified using standard protein purification techniques such as size exclusion and chromatography. The result is an extremely efficient monoclonal antibody to THBD Marker.

The monoclonal antibody for THBD Marker has been developed to detect Glycophorin A that is produced by the human eukaryotic cell Kluyveromyces host. The cDNA is encoding heavy chain-only antibody is made by segments of oligonucleotide that overlap and is created into an expression vector. The cDNA fragment is containing URA3 followed by CEN4 and Pm1I, as well as SphI digests of pBACBelo11.

The Monoclonal Antibody to THBP is an immunegen with numerous effector functions. These functions are essential to the diagnosis and analysis of various diseases and conditions. These include Alzheimer's disease and asthmatic bronchial edema, atopic allergy, atherosclerosis and osteoarthritis.

THBD Marker, a common protein that is found in various tissues, includes bone Marrow, which is a typical one. It is also found in healthy people's blood. There are many formats of Anti-GlycophorinA / CD235a. Online purchase of monoclonal antibodies in different concentrations is feasible for research and diagnostic purposes.

Boster Bio's Multichannel Pipette

Multichannel pipettes are a fantastic tool for performing enzymatic reactions. This tool is particularly useful when using 384-well plates. These pipettes have an electronic design and have a contemporary design. Multichannel pipettes are a fantastic choice for large volumes of studies. They are available in single channel or multichannel versions. They're a great choice for those looking to maximize their efficiency while minimising waste.

Steven Boster's story

Stephen Boster, 73, passed away from COVID-19 on March 31 March 31, 2019. He was the husband and father of Mary Pitts, a former basketball player at the University of Georgia. His extended family now includes six children and nine grandchildren. Steve was a huge supporter of opposing sports teams and enjoyed playing them. He also enjoyed auto racing, and was the first to be at an auto that was broken down even in temperatures below freezing. He treated his family and friends with the same kindness as his own family.