TDO2 Antibodies

AND TDO2 ELISA kits, TDO2 Proteins

Many biological assays use antibodies to detect TDO2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TDO2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TDO2 antibodies...

We validate the specificity of these antibodies to TDO2 by testing them on tissues known to express TDO2 positively and negatively. Browse below to find the TDO2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TDO2 Infographic by Boster Bio

All TDO2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human TDO2 Recombinant Protein

SDS-PAGE

$350
Cat # PROTP48775
Starting from 10ug

Anti-TDO2 Mouse Monoclonal Antibody [Clone ID: OTI2A4]

Human, Mouse, Rat

IHC, WB

$523
Cat # M07526
100 µl

TDO2 (NM_005651) Human Over-expression Lysate

Human

$628
Cat # LS006999
100 µg

TDO2 Overview

Facts about Tryptophan 2,3-dioxygenase.

TDO2 3D structure. Source: alphafold

Tryptophan 2,3-dioxygenase (TDO2)

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan into N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Gene Information

Human
Gene Name:	TDO2
Uniprot:	P48775
Entrez:	6999

Family

Belongs to:

tryptophan 2,3-dioxygenase family

Alternative Names

chky; TDO; TDO2; TDOTO; TO; TPH2EC 1.13.11.11; TRPO; TRPOtryptophanase; Tryptamin 2,3-dioxygenase; tryptophan 2,3-dioxygenase; Tryptophan Oxygenase; Tryptophan Pyrrolase; Tryptophanase

Molecular Weight

Mass (kDA):
47.872 kDA

Genomic Context


Human

Location:	4q32.1
Sequence:	4; NC_000004.12 (155903696..155920406)

Diseases

Mental Disorders
Schizophrenia
Depressive Disorder
Bipolar Disorder
Psychotic Disorders
Gilles De La Tourette Syndrome
Malnutrition
Neurodegenerative Disorders
Attention Deficit Hyperactivity Disorder
Postmortem Changes
Cholangiocarcinoma

Hyperhomocysteinemia
Substance-related Disorders
Dementia
Behavioral Tic
Pre-eclampsia
Infertility

Interacting Proteins

ASMTL
DPM1
EIF4E
MOB1A
MOB3C

NGB
NMNAT1
PICK1
PM20D2
SDCBP

SDCBP2

Pathways

Aging
Transport
Regeneration
Decidualization
Hyperphosphorylation
Transmembrane Transport
Liver Regeneration
Neurogenesis
Mating

Wound Healing
Pathogenesis
Localization

PTMs

Phosphorylation

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TDO2

References

PMID: 8666386 by Comings D.E., et al. Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat.

PMID: 28285122 by Ferreira P., et al. Hypertryptophanemia due to tryptophan 2,3-dioxygenase deficiency.