TCIM Antibodies

AND TCIM ELISA kits, TCIM Proteins

Many biological assays use antibodies to detect TCIM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TCIM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TCIM antibodies...

We validate the specificity of these antibodies to TCIM by testing them on tissues known to express TCIM positively and negatively. Browse below to find the TCIM antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TCIM Infographic by Boster Bio

All TCIM Products

Product

Figures

Specificity

Applications

Price

Anti-C8orf4 TCIM Antibody

Human, Mouse, Rat

IHC, WB

$405
Cat # A31995
100ul

TCIM (NM_020130) Human Over-expression Lysate

Human

$628
Cat # LS056892
100 µg

TCIM Overview

Facts about Transcriptional and immune response regulator.

TCIM 3D structure. Source: alphafold

Transcriptional and immune response regulator (TCIM)

Appears to be involved in the regulation of cell growth an differentiation, may play different and opposite functions depending on the cell or tissue type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic action of CBY1 (PubMed:16424001, PubMed:16730711).

Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen- activated MAPK2/3 signaling pathway, positively regulates G1-to-S- phase transition of the cell cycle (PubMed:18959821).

Gene Information

Human
Gene Name:	TCIM
Uniprot:	Q9NR00
Entrez:	56892

Family

Belongs to:

No superfamily

Alternative Names

Transcriptional and immune response regulator

Molecular Weight

Mass (kDA):
12.337 kDA

Genomic Context


Human

Location:	8p11.21
Sequence:	8; NC_000008.11 (40153482..40155310)

Tissue Specificity

Ubiquitous. Expressed in thyroid papillary carcinoma. Expressed in liver, expression levels decrease in hepatocellular carcinoma (PubMed:25985737). Slightly detected in normal lung, its expression is highly induced in lung cancer cells (at protein level) (PubMed:24941347).

Subcellular Localizations

Cytoplasm. Nucleus, nucleolus. Nucleus speckle. Nucleus. Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013).

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TCIM

References

PMID: 11056052 by Chua E.L., et al. Cloning of TC-1 (C8orf4), a novel gene found to be overexpressed in thyroid cancer.

PMID: 15087392 by Sunde M., et al. TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.