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- Table of Contents
Facts about Thioredoxin reductase 2, mitochondrial.
May play a role in redox-regulated cell signaling. .
Human | |
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Gene Name: | TXNRD2 |
Uniprot: | Q9NNW7 |
Entrez: | 10587 |
Belongs to: |
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class-I pyridine nucleotide-disulfide oxidoreductase family |
EC 1.8.1; EC 1.8.1.9; KIAA1652; Selenoprotein Z; SelZ; Thioredoxin Reductase 2; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR3; TR-beta; TRXR2; TRXR2thioredoxin reductase 2, mitochondrial; TXNRD2
Mass (kDA):
56.507 kDA
Human | |
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Location: | 22q11.21 |
Sequence: | 22; NC_000022.11 (19875518..19941818, complement) |
Highly expressed in the prostate, ovary, liver, testis, uterus, colon and small intestine. Intermediate levels in brain, skeletal muscle, heart and spleen. Low levels in placenta, pancreas, thymus and peripheral blood leukocytes. According to PubMed:10608886, high levels in kidney, whereas according to PubMed:9923614, levels are low. High expression is observed in the adrenal cortex (PubMed:24601690).
Mitochondrion.
PMID: 10455115 by Sun Q.-A., et al. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases.
PMID: 9923614 by Gasdaska P.Y., et al. Cloning, sequencing and functional expression of a novel human thioredoxin reductase.