MTHFS Antibodies

AND MTHFS ELISA kits, MTHFS Proteins

Many biological assays use antibodies to detect MTHFS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MTHFS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MTHFS antibodies...

We validate the specificity of these antibodies to MTHFS by testing them on tissues known to express MTHFS positively and negatively. Browse below to find the MTHFS antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MTHFS Infographic by Boster Bio

All MTHFS Products

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Specificity

Applications

Price

MTHFS (NM_006441) Human Recombinant Protein

$813
Cat # PROTP49914
20 µg

MTHFS (NM_006441) Human Over-expression Lysate

Human

$628
Cat # LS010588
100 µg

MTHFS Overview

Facts about 5-formyltetrahydrofolate cyclo-ligase.

MTHFS 3D structure. Source: alphafold

5-formyltetrahydrofolate cyclo-ligase (MTHFS)

Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that provides carbon for the biosynthesis of purines, thymidine and amino acids.

Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate. .

Gene Information

Human
Gene Name:	MTHFS
Uniprot:	P49914
Entrez:	10588

Family

Belongs to:

5-formyltetrahydrofolate cyclo-ligase family

Alternative Names

5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolatecyclo-ligase); 5-formyltetrahydrofolate cyclo-ligase; EC 6.3.3.25,10-methenyl-tetrahydrofolate synthetase; FLJ30410; HsT19268; Methenyl-THF synthetase

Molecular Weight

Mass (kDA):
23.256 kDA

Genomic Context


Human

Location:	15q25.1
Sequence:	15; NC_000015.10 (79843547..79897285, complement)

Subcellular Localizations

Cytoplasm.

Diseases

5,10-methylenetetrahydrofolate Reductase Deficiency
Malignant Neoplasms
Neuroblastoma
Neoplasms
Lymphoma
Pneumonia
Carcinoma
Leukemogenesis
Atherosclerosis
Kidney Diseases
Lymphoma, Non-hodgkin
Cholangiocarcinoma
Burkitt Lymphoma

Diabetic Nephropathy
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung
Cardiovascular Diseases
Congenital Heart Defects
Chronic Kidney Disease
Mammary Neoplasms

Pathways

Methylation
Cell Division
Transsulfuration
Cell Proliferation
Dna Methylation
Cell Growth

Glomerular Filtration

PTMs

Methylation
Phosphorylation

Formylation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MTHFS

References

PMID: 8522195 by Dayan A., et al. Cloning and characterization of the human 5,10- methenyltetrahydrofolate synthetase-encoding cDNA.

PMID: 3801490 by Bertrand R., et al. Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates.