TXN2 Antibodies

Thioredoxin, mitochondrial (TXN2)

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.

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Gene Information

Human
Gene Name:	TXN2
Uniprot:	Q99757
Entrez:	25828

Family

Belongs to:
thioredoxin family

Alternative Names

mitochondrial thioredoxin; MTRX; MT-TRX; thioredoxin 2; thioredoxin, mitochondrial; Thioredoxin2; Thioredoxin-2; Trx2; TXN2

Molecular Weight

Mass (kDA):
18.383 kDA

Genomic Context

Human
Location:	22q12.3
Sequence:	22; NC_000022.11 (36467036..36481672, complement)

Tissue Specificity

Widely expressed in adult (at protein level) and fetal tissues.

Subcellular Localizations

Mitochondrion.

Diseases

• Malignant Neoplasm Of Breast
• Malignant Neoplasms
• Neoplasms
• Mammary Neoplasms
• Carcinoma
• Hypoxia
• Inflammation
• Retinal Diseases
• Brain Injuries
• Diabetes Mellitus
• Ductal Breast Carcinoma
• Carcinoma, Lobular

• Malignant Squamous Cell Neoplasm
• Hyperplasia
• Local Disease
• Stomach Neoplasms
• Neoplasm Metastasis
• Mastitis-metritis-agalactia Syndrome
• Radiation Injuries, Experimental

Interacting Proteins

• AGTRAP
• AP2B1
• CCDC114
• DCTD
• FAM9B

• GPRASP2
• KRT40
• MAPRE2
• MAPRE3
• MRFAP1L1

• MTUS2
• PPCDC
• PSME3
• RABGEF1
• RBM45

• REEP6
• RPIA
• SCYL3
• SSNA1
• STUB1

• TIFA
• TRIM21
• TRIP6
• VPS52
• ZBTB14

Pathways

• Cell Death
• Aging
• Response To Oxidative Stress
• Cell Proliferation
• Transport
• Electron Transport
• Electron Transport Chain
• Release Of Cytochrome C From Mitochondria
• Cell Growth
• Protein Phosphorylation
• Neural Tube Closure
• Gene Silencing
• Programmed Cell Death

• Cellular Homeostasis
• Mitochondrial Outer Membrane Permeabilization
• Oxidative Phosphorylation
• Metestrus
• Mitochondrial Translocation
• Regulation Of Histone Acetylation
• Membrane Depolarization

PTMs

• Oxidation
• Reduction
• Cleavage

• Phosphorylation
• Nitrosylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TXN2

Best Uses Of The TXN2 Marker

The TXN2 marker is a biomarker for TXN2 which is a protein that regulates cell death, proliferation and differentiation. Boster offers high-affinity primary antibodies. It is important to understand how the TXN2 marker functions. In this article, we'll explain how this biomarker operates and what scientists can do to get the most benefit of it.

Boster provides high-affinity primary antibody

As a primary antibody producer, Boster Bio is proud to provide high-affinity primary antibody against the TxN2 marker. These antibodies are available in monoclonal as well in polyclonal versions. They can be utilized in flow cytometry, an instrument used to analyze biological samples and cells. They are an excellent choice for researchers searching for an individual marker to study.

These antibodies are created to recognize TXN2 the enzyme that is found in mammalian cells. Dual-labeled versions are also available. This allows researchers to ask multiple questions simultaneously and gain more context. Dual-labeling is particularly useful when TXN2 is detected in blood, tissues, and other tissues. High-affinity primary antibodies against the TXN2 marker from Boster Bio offer superior results and are designed for researchers looking to identify the disease-causing enzyme in their samples.

CD40 regulates cell proliferation, differentiation, and death

TXN2 stands for thioredoxin-2. The TXN2 gene is located on chromosome 22, and encodes an element of the thioredoxin family a group of small multifunctional active proteins that redox. The TXN2 protein may be a key player in mitochondrial membrane potential as well as protection against death caused by oxidants. To ensure reproducibility, Boster validates antibodies against known negative and positive samples.

Cell death regulates cell proliferation, differentiation, and cell death

In eukaryotic cells the process of dying cells is vital to the maintenance of homeostasis in tissues, organism development and defense against the host. A variety of mechanisms control the onset and progression of cell death that include signal transduction proteins. Different types of cell death are crucial for a variety physical conditions, including cancer and aging. Below are the main factors that regulate cell death and their regulation.

The regulation of cell death happens in a variety of ways and is the most important of them all. Cell death is triggered by numerous triggers, including the immune response to an invading disease agent. Activation of pattern recognition receptors (PRRs) triggers the release of mediators insoluble and Apoptosis. Toxins, cathepsin activity , and reactive oxygen species can trigger cell death.

After death, the mitogenic signals of apoptotic cells are released. Some models show that apoptotic cells release Hedgehog (the vertebrate ortholog of the Sonic hedgehog), which causes eye growth. In zebrafish cells, apoptotic cells secrete proliferative factors such as DPP. The proliferation of cells around them will then continue unabated.

The protein PDCD5 (programmed cell death) is an example of this type of regulation. The gene was cloned from the human leukemia cell line, TF-1. It spans six kb of genomic DNA and encodes a protein of 125-aa. It plays various roles in different cell types and is usually involved in tumor growth. This protein also regulates cell cycle progression.

In embryonic mouse brain, PAR-4 and ceramide levels are raised during the peak of apoptosis, suggesting the role of ceramide in controlling NP cell death. The apoptotic pathway block PAR-4 and DRONC, thereby activating DIAP1 function and DRONC, and activating JNK triggers transcriptional inhibition of mitogens, such as the apoptotic and PD-1.

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