TWSG1 Antibodies

AND TWSG1 ELISA kits, TWSG1 Proteins

Many biological assays use antibodies to detect TWSG1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TWSG1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TWSG1 antibodies...

We validate the specificity of these antibodies to TWSG1 by testing them on tissues known to express TWSG1 positively and negatively. Browse below to find the TWSG1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TWSG1 Infographic by Boster Bio

All TWSG1 Products

Product

Figures

Specificity

Applications

Price

TSG Twisted Gastrulation Protein Human Recombinant Protein

Human

$250
Cat # PROTQ9GZX9
10ug, 50ug, 1mg

TWSG1 (NM_020648) Human Over-expression Lysate

Human

$628
Cat # LS057045
100 µg

TWSG1 Overview

Facts about Twisted gastrulation protein homolog 1.

TWSG1 3D structure. Source: alphafold

Twisted gastrulation protein homolog 1 (TWSG1)

May be involved in dorsoventral axis formation. Appears to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors.

In addition to the anti-BMP function, also has pro-BMP activity, partially mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. Might be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation.

Gene Information

Human
Gene Name:	TWSG1
Uniprot:	Q9GZX9
Entrez:	57045

Family

Belongs to:

twisted gastrulation protein family

Alternative Names

TSG; TSGtwisted gastrulation protein homolog 1; twisted gastrulation homolog 1 (Drosophila); TWSG1

Molecular Weight

Mass (kDA):
25.017 kDA

Genomic Context


Human

Location:	18p11.22
Sequence:	18; NC_000018.10 (9334773..9402420)

Subcellular Localizations

Secreted.

Diseases

Holoprosencephaly
Craniofacial Abnormalities
Malignant Neoplasms
Osteopenia
Congenital Absence Of Jaw
Cholangiocarcinoma
Desmoplastic
Periodontitis
Malignant Neoplasm Of Breast
Hydrocephalus
Carcinoma
Dysplasia

Multiple Myeloma
Osteoporosis
Cytogenetic Abnormality
Thalassemia
Anemia
Liver Carcinoma
Intrahepatic Cholangiocarcinoma

Interacting Proteins

SGTA

Pathways

Gastrulation
Osteoclast Differentiation
Bone Remodeling
Cell-cell Signaling
Brain Development
Glycosylation
Cell Fate Determination
Localization
Coagulation
Paracrine Signaling
Osteoclast Proliferation

Cell Differentiation
Forebrain Development
Regulation Of Osteoclast Differentiation
Bone Resorption
Tissue Homeostasis

PTMs

Phosphorylation

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TWSG1

References

PMID: 11260715 by Scott I.C., et al. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling.

PMID: 11420619 by Graf D., et al. Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation.