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Twist-related protein 2 Antibodies
AND Twist2 ELISA kits, Twist-related protein 2 Proteins
Many biological assays use antibodies to detect Twist-related protein 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Twist-related protein 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Twist-related protein 2 antibodies...
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Twist2 Infographic by Boster Bio
All Twist2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M04422
100 µl
Cat # M04422
100 µl
Twist2 Overview
Facts about Twist-related protein 2.
Twist-related protein 2 (Twist2)
Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines like TNFA and IL1B.
Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Twist2 |
| Uniprot: | Q9D030 |
| Entrez: | 13345 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
bHLHa39; bHLHa39twist-related bHLH protein Dermo1; Class A basic helix-loop-helix protein 39; Dermis-expressed protein 1; DERMO1; Dermo-1; DERMO1MGC117334; twist homolog 2 (Drosophila); Twist2; Twist-2; twist-related protein 2
Molecular Weight
Mass (kDA):
18.14 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 1|1 D |
| Sequence: | 1; |
Tissue Specificity
Expressed at low levels in sclerotome and dermatome of somites, and in limb buds at 10.5 dpc. Accumulates predominantly in dermatome, prevertebrae and derivatives of branchial arches by 13 dpc. Also expressed near surface of embryo and in chondrogenic cells. In adult, expressed at low levels in skin, bladder, uterus, aorta and heart.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Carcinoma
- Cell Invasion
- Neoplasm Invasiveness
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Hypoxia
- Crest Syndrome
- Carcinogenesis
Pathways
- Localization
- Osteoblast Differentiation
- Epithelial To Mesenchymal Transition
- Senescence
- Cell Death
- Cell Differentiation
- Cell Proliferation
- Bone Development
- Histone Acetylation
- Programmed Cell Death
- Cell Fate Determination
- Reverse Transcription
- Cell Cycle
PTMs
- Phosphorylation
- Acetylation
Research Areas
- Inhibitors, Activators and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Twist2
bosterbio.com/bosterbio-gene-info-cards/Twist2
References
PMID: 7589808 by Li L., et al. Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis.
PMID: 11809751 by Gong X.Q., et al. Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylation.