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- Table of Contents
Facts about Twinfilin-1.
By capping the barbed ends of filaments, in addition, it regulates motility. Seems to play an important role in clathrin-mediated endocytosis and supply of endocytic organelles (By similarity).
Human | |
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Gene Name: | TWF1 |
Uniprot: | Q12792 |
Entrez: | 5756 |
Belongs to: |
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actin-binding proteins ADF family |
A6 protein tyrosine kinase; A6; Protein A6; Protein tyrosine kinase 9MGC23788; PTK9 protein tyrosine kinase 9; PTK9MGC41876; twinfilin, actin-binding protein, homolog 1 (Drosophila); twinfilin-1
Mass (kDA):
40.283 kDA
Human | |
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Location: | 12q12 |
Sequence: | 12; NC_000012.12 (43793723..43806317, complement) |
Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver.
Cytoplasm. Cytoplasm, cytoskeleton. Diffuse cytoplasmic localization with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell contacts (By similarity).
PMID: 7507208 by Beeler J.F., et al. Prokaryotic expression cloning of a novel human tyrosine kinase.
PMID: 28493397 by Rainger J., et al. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.