TUBGCP2 Antibodies

Gamma-tubulin complex component 2 (TUBGCP2)

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. .

Gene Information

Human
Gene Name:	TUBGCP2
Uniprot:	Q9BSJ2
Entrez:	10844

Family

Belongs to:
TUBGCP family

Alternative Names

Gamma-ring complex protein 103 kDa; gamma-tubulin complex component 2; gamma-tubulin complex protein 2; GCP-2; GCP2hGrip103; h103p; hGCP2; hSpc97; MGC138162; SPBC97; Spc97p; Spindle pole body protein Spc97 homolog; tubulin, gamma complex associated protein 2

Molecular Weight

Mass (kDA):
102.534 kDA

Genomic Context

Human
Location:	10q26.3
Sequence:	10; NC_000010.11 (133278630..133312337, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Diseases

• Cell Transformation, Neoplastic
• Congenital Abnormality
• Behcet Syndrome
• Osteoarthritis, Knee
• Aneuploidy
• Diabetes Mellitus
• Degenerative Polyarthritis
• Leukemia, Myelocytic, Acute
• Arthritis
• Cardiovascular Diseases
• Greig Cephalopolysyndactyly Syndrome
• Brucellosis
• Neoplasms

• Myeloid Leukemia
• Familial Mediterranean Fever
• Leukemia
• 5,10-methylenetetrahydrofolate Reductase Deficiency
• Dental Plaque
• Synovitis
• Rheumatoid Arthritis

Pathways

• Microtubule Nucleation
• Mitosis
• Localization
• Cell Cycle
• Cell Division
• Interphase
• Chromosome Segregation
• Sexual Reproduction
• Cell Death

• Spindle Organization
• Centrosome Duplication
• Microtubule Polymerization
• Spindle Assembly

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TUBGCP2

Best Uses Of The TUBGCP2 Marker

It's crucial to understand the cost and potential uses of the TUBGCP2 TUBGCP2 marker if you are going to analyze it in your research. It's more than just for researchers. Scientists all over the world can use this test to find out how specific a gene is. It can also be used in order to determine the genetic makeup of a particular species. This information can prove extremely useful when testing special samples.

TUBGCP2Marker

A protein tagged with the TUBGCP2 gene has several applications. This gene can be used for immunoprecipitation or Western Blot techniques. The protein sequence for this gene is AA. It can also be used in many other applications. However, the sequence cannot be used for all applications. To ensure that TUBGCP2 is properly expressed in a particular cell, it must also be translated into the native protein.

Applications

The TUBGCP2 gene is a key component of the protein that regulates the cell cycle. This gene is essential for cell division and survival and is expressed throughout the life cycle. Mutations in TUBGCP2 may lead to a variety developmental defects and phenotypes. Tubegcp3 mutations are also known as tubgcp3 mice, and they are often inbred with wild-type mice.

The TUBGCP2 protein code encodes the tubulin family component TUBGCP2. It plays an important part in microtubule cleation and is mostly found in spindlepole bodies and centrosomes. This protein is found in all cells and is used as a loading control in western-blot experiments. TUBGCP2 can also act as a marker to microtubule fusions.

The tubgcp3 CMZ mutation inhibits both cell differentiation and proliferation. Centrioles are necessary for mitosis to occur evenly and segregate. Tubgcp3 mutants have an abnormal centriole distribution, forming four dots per centriole. The resulting cell cycling is incomplete and asymmetrical. Tubgcp3 might contribute to the growth of cancer.

The TUBGCP2 genetic code is essential for the assembly the g–TuRC component of the centralosome. Premature senescence could be a possible explanation for this condition. More research is needed on the relationship between microcephaly disorder and centrosome functioning. This gene is critical for gTuRC function, but it is essential for many other functions.

Specificity

The TUBGCP2 genome encodes a dimeric proteomic that plays a role in the formation and maintenance of microtubules. Microtubules, which are important intracellular structures that are involved in fundamental processes, are key components of the TUBGCP2 gene. Many people believe tubulin to not be a very interesting gene product. In fact, tubulin plays a central role in the formation of microtubules.

The TUBGCP2 gene encodes accessory proteins that are homologous to animal g-tubulin ring complexes. They are essential for centriole integrity and chromosome stability as well as segregation. The TUBGCP2 gene is located in centrioles. This is where it is needed for chromosome segregation as well as spindle integrity. The marker is capable of distinguishing between different types.

The TUBGCP2 gene is present in all organs. Different tissues and organs may express the gene differently. Tubulin mutations can affect the GTPase activated region, the longitudinal interfacing between two tubulin subunits, as well as the lateral contact regions between adjacent profilaments. Mutated tubulin protein can also cause heterotaxia in plants.

Cost

TUBGCP2 is a protein encoded by g-tubulin. It is similar to tubgcp3's expression and is thought to play a role in cell proliferation. It is unknown what exact role TUBGCP3 has in cell proliferation. This research is currently being published in the Journal of Cell Biology. TUBGCP2 plays an important role in the human genetic code. It costs around $1.20 a mole.

Availability

Availability of the TUBGCP2 gene is required for the localization of MTs, the cargo molecules carried by tubulin. The multi-tubulin hypothesis, which was first proposed 36 years back, has been largely disproven. Tubulin research continues to make exciting contributions to cell biology and protein biochemistry. We will be discussing its role in gene regulation.