Titin Antibodies

AND TTN ELISA kits, Titin Proteins

Many biological assays use antibodies to detect Titin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Titin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Titin antibodies...

We validate the specificity of these antibodies to Titin by testing them on tissues known to express TTN positively and negatively. Browse below to find the TTN antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TTN Infographic by Boster Bio

All TTN Products

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Anti-TTN/Titin Antibody

3 Q&As

Human, Mouse, Rat

IHC

$399
Cat # A00540
100μl

Anti-TTN Antibody (N-term)

Human

IHC-P

$299
Cat # M00540
50 µl

TTN Overview

Facts about Titin.

Titin (TTN)

Key component in the assembly and functioning of vertebrate striated muscles. By giving connections at the level of human microfilaments, it contributes to the fine balance of forces between the two parts of the sarcomere.

The size and extensibility of the cross-links are the chief determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis.

Gene Information

Human
Gene Name:	TTN
Uniprot:	Q8WZ42
Entrez:	7273

Family

Belongs to:

protein kinase superfamily

Alternative Names

cardiomyopathy, dilated 1G (autosomal dominant); CMD1G; CMH9; CMPD4; connectin; DKFZp451N061; EC 2.7.11.1; EOMFC; FLJ32040; FLJ34413; FLJ39564; FLJ43066; HMERF; LGMD2JFLJ26020; MPRM; Rhabdomyosarcoma antigen MU-RMS-40.14; titin; TMDFLJ26409

Molecular Weight

Mass (kDA):
3816.03 kDA

Genomic Context


Human

Location:	2q31.2
Sequence:	2; NC_000002.12 (178525989..178807423, complement)

Tissue Specificity

Isoforms 3, 7 and 8 are expressed in cardiac muscle. Isoform 4 is expressed in vertebrate skeletal muscle. Isoform 6 is expressed in skeletal muscle (at protein level).

Subcellular Localizations

Cytoplasm. Nucleus.

Diseases

Tachypnea
Transitory Tachypnea Of Newborn
Cardiomyopathies
Respiratory Distress
Respiratory Distress Syndrome, Newborn
Cardiomyopathy, Dilated
Myopathy
Hypertrophy
Dystrophy
Respiration Disorders
Malignant Neoplasms
Muscular Dystrophy

Cardiomyopathy, Familial Idiopathic
Heart Failure
Neoplasms
Hypertrophic Cardiomyopathy
Thyroid Nodule
Weakness
Pneumonia

Interacting Proteins

ACTN1
ACTN2
CAPN3
DNAJB5
DYSF

ENO1
MYBPC2
MYBPH
MYOM2
NEB

OBSCN
OBSL1
OPTN
SYNM
TCAP

TRIM63

Pathways

Secretion
Pathogenesis
Regeneration
Seed Development
Localization
Cell Proliferation
Mitosis
Cell Differentiation
Transport
Fertilization
Phagocytosis
Cell Cycle
Aldosterone Secretion

Insulin Secretion
Endosperm Development
Cell Adhesion
Cell Migration
Glial Cell Proliferation
Dosage Compensation
Myelination

PTMs

Oxidation
Phosphorylation
Cleavage

Nitration
Biotinylation
Glycosylation

Decarboxylation

Research Areas

Cancer
Cell Biology
Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TTN

References

PMID: 7569978 by Labeit S., et al. Titins, giant proteins in charge of muscle ultrastructure and elasticity.

PMID: 10850961 by Freiburg A., et al. Series of exon-skipping events in the elastic spring region of titin as the structural basis for myofibrillar elastic diversity.