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- Table of Contents
Facts about Tetratricopeptide repeat protein 28.
Human | |
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Gene Name: | TTC28 |
Uniprot: | Q96AY4 |
Entrez: | 23331 |
Belongs to: |
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No superfamily |
Tetratricopeptide repeat protein 28
Mass (kDA):
270.884 kDA
Human | |
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Location: | 22q12.1 |
Sequence: | 22; NC_000022.11 (27978014..28679865, complement) |
Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas.
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Midbody. At interphase, localizes to centrosomes. At prometaphase and metaphase, associated with spindle microtubules and spindle poles. At anaphase, accumulates in the spindle midzone. At telophase, condensed on central spindles. During cytokinesis, condensed on the midbody where it colocalizes with AURKB (By similarity).
PMID: 23036704 by Izumiyama T., et al. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis.