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TSC22D3 Antibodies
AND TSC22D3 ELISA kits, TSC22D3 Proteins
Many biological assays use antibodies to detect TSC22D3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TSC22D3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TSC22D3 antibodies...
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TSC22D3 Infographic by Boster Bio
All TSC22D3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, IF, IHC-P, WB
$449
Cat # A03078
0.1 mg
Cat # A03078
0.1 mg
Human, Mouse
IF, WB
$523
Cat # M03078
100 µl
Cat # M03078
100 µl
TSC22D3 Overview
Facts about TSC22 domain family protein 3.
TSC22 domain family protein 3 (TSC22D3)
Protects T-cells out of IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of this pro-apoptotic variable BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10.
In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | TSC22D3 |
| Uniprot: | Q99576 |
| Entrez: | 1831 |
Family
| Belongs to: |
|---|
| TSC-22/Dip/Bun family |
Alternative Names
Delta sleep-inducing peptide immunoreactor; DSIP-immunoreactive leucine zipper protein; DSIP-immunoreactive peptide; GILZDKFZp313A1123; Glucocorticoid-induced leucine zipper protein; Protein DIP; TSC22 domain family protein 3; TSC22 domain family, member 3; TSC-22 related protein; TSC-22-like protein; TSC-22-related protein; TSC-22Rimmunoreactor
Molecular Weight
Mass (kDA):
14.81 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq22.3 |
| Sequence: | X; NC_000023.11 (107713221..107777329, complement) |
Tissue Specificity
Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down- regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
Subcellular Localizations
[Isoform 1]: Cytoplasm. Nucleus. Localization depends on differentiation status of myoblasts. In undifferentiated myoblasts, isoform 1 localizes to the cytoplasm, but in differentiating myoblasts, isoform 1 is localized to the nucleus (By similarity).
Diseases
- Inflammation
- Leukemia
- Malignant Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Acute Lymphocytic Leukemia
- Asthma
- Epithelial Ovarian Cancer
- Ovarian Neoplasm
- L1 Acute Lymphoblastic Leukemia
- Precursor T-cell Lymphoblastic Leukemia-lymphoma
- Haploinsufficiency
Interacting Proteins
- C19orf57
- MAD1L1
Pathways
- Transport
- Cell Proliferation
- Cell Death
- Immune Response
- Pathogenesis
- Secretion
- Cytokine Secretion
- Translation
- Cell Cycle
- Localization
- Macrophage Activation
- Cell Activation
- Gene Silencing
PTMs
- Phosphorylation
Research Areas
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TSC22D3
bosterbio.com/bosterbio-gene-info-cards/TSC22D3
References
PMID: 8982256 by Vogel P., et al. hDIP -- a potential transcriptional regulator related to murine TSC- 22 and Drosophila shortsighted (shs) -- is expressed in a large number of human tissues.
PMID: 11313722 by Cannarile L., et al. Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene.