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TRPV6 Antibodies
AND TRPV6 ELISA kits, TRPV6 Proteins
Many biological assays use antibodies to detect TRPV6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPV6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPV6 antibodies...
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TRPV6 Overview
Facts about Transient receptor potential cation channel subfamily V member 6.
Transient receptor potential cation channel subfamily V member 6 (TRPV6)
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980, PubMed:29258289). Important for normal Ca(2+) ion homeostasis in the body, including skin and bone (By similarity).
The channel is activated by low internal calcium level, likely including intracellular calcium store depletion, and the present exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)- dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be controlled by phosphorylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRPV6 |
| Uniprot: | Q9H1D0 |
| Entrez: | 55503 |
Family
| Belongs to: |
|---|
| transient receptor (TC 1.A.4) family |
Alternative Names
ABP/ZF; calcium channel CaT1; Calcium transport protein 1; CaT1; CATL; CaT-L; CaT-like; ECAC2; ECAC2caT-L; epithelial apical membrane calcium transporter/channel CaT1; Epithelial calcium channel 2Alu-binding protein with zinc finger domain; HSA277909; LP6728; transient receptor potential cation channel subfamily V member 6; transient receptor potential cation channel, subfamily V, member 6; TRPV6; ZFAB
Molecular Weight
Mass (kDA):
87.286 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q34 |
| Sequence: | 7; NC_000007.14 (142871208..142885745, complement) |
Tissue Specificity
Expressed at high levels in the gastrointestinal tract, including esophagus, stomach, duodenum, jejunum, ileum and colon, and in pancreas, placenta, prostate and salivary gland. Expressed at moderate levels in liver, kidney and testis. Expressed in trophoblasts of placenta villus trees (at protein level)(PubMed:23612980). Expressed in locally advanced prostate cancer, metastatic and androgen-insensitive prostatic lesions but not detected in healthy prostate tissue and benign prostatic hyperplasia.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Hypercalciuria
- Osteoporosis
- Leukemia
- Hypocalcemia
- Rickets
- Hypercalcemia
- Carcinoma
- Carcinogenesis
Interacting Proteins
- PTPN1
Pathways
- Transport
- Excretion
- Intestinal Absorption
- Cell Proliferation
- Cell Cycle
- Aging
- Localization
- Secretion
- Cell Death
- Pathogenesis
- Bone Mineralization
- Bone Resorption
- Embryo Implantation
PTMs
- Phosphorylation
- Glycosylation
- Acetylation
- Dephosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPV6
bosterbio.com/bosterbio-gene-info-cards/TRPV6
References
PMID: 11097838 by Peng J.-B., et al. Human calcium transport protein CaT1.
PMID: 11545681 by Wood R.J., et al. 1,25-dihydroxyvitamin D3 increases the expression of the CaT1 epithelial calcium channel in the Caco-2 human intestinal cell line.