TRPM6 Antibodies

AND TRPM6 ELISA kits, TRPM6 Proteins

Many biological assays use antibodies to detect TRPM6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRPM6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRPM6 antibodies...

We validate the specificity of these antibodies to TRPM6 by testing them on tissues known to express TRPM6 positively and negatively. Browse below to find the TRPM6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRPM6 Infographic by Boster Bio

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TRPM6 Overview

Facts about Transient receptor potential cation channel subfamily M member 6.

TRPM6 3D structure. Source: alphafold

Transient receptor potential cation channel subfamily M member 6 (TRPM6)

Essential ion channel and serine/threonine-protein kinase. Vital for magnesium homeostasis.

Has an essential part in epithelial magnesium transport and at the active magnesium absorption in the gut and kidney. Isoforms of the type M6-kinase lack the ion channel area.

Gene Information

Human
Gene Name:	TRPM6
Uniprot:	Q9BX84
Entrez:	140803

Family

Belongs to:

No superfamily

Alternative Names

Transient receptor potential cation channel subfamily M member 6

Molecular Weight

Mass (kDA):
231.708 kDA

Genomic Context


Human

Location:	9q21.13
Sequence:	9; NC_000009.12 (74722495..74887921, complement)

Tissue Specificity

Highly expressed in kidney and colon. Isoform TRPM6a and isoform TRPM6b, are coexpressed with TRPM7 in kidney, and testis, and are also found in several cell lines of lung origin. Isoform TRPM6c is detected only in testis and in NCI-H510A small cell lung carcinoma cells.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRPM6

References

PMID: 11357414 by Riazanova L.V., et al. Novel type of signaling molecules: protein kinases covalently linked to ion channels.

PMID: 12032568 by Schlingmann K.P., et al. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family.