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- Table of Contents
Facts about Transient receptor potential cation channel subfamily M member 1.
May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel.
Human | |
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Gene Name: | TRPM1 |
Uniprot: | Q7Z4N2 |
Entrez: | 4308 |
Belongs to: |
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transient receptor (TC 1.A.4) family |
CSNB1C; Long transient receptor potential channel 1; LTrpC1; LTRPC1transient receptor potential cation channel subfamily M member 1; melastatin 1; melastatin-1; MLSN; MLSN1transient receptor potential melastatin family; transient receptor potential cation channel, subfamily M, member 1
Mass (kDA):
182.178 kDA
Human | |
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Location: | 15q13.3 |
Sequence: | 15; NC_000015.10 (31001061..31161273, complement) |
Expressed in the retina where it localizes to the outer plexiform layer. Highly expressed in benign melanocytic nevi and diffusely expressed in various in situ melanomas, but not detected in melanoma metastases. Also expressed in melanocytes and pigmented metastatic melanoma cell lines. In melanocytes expression appears to be regulated at the level of transcription and mRNA processing.
Cell membrane; Multi-pass membrane protein.
PMID: 9806836 by Hunter J.J., et al. Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1).
PMID: 19436059 by Oancea E., et al. TRPM1 forms ion channels associated with melanin content in melanocytes.