tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial (TRMT61B)

Methyltransferase that catalyzes the formation of N(1)- methyladenine at position 58 (m1A58) in a variety of tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1- methyladenosine at stake 947 of mitochondrial 16S ribosomal RNA and this modification is probably essential for mitoribosomal structure and function (PubMed:27631568).

In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)- methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). .