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- Table of Contents
Facts about Multifunctional methyltransferase subunit TRM112-like protein.
The heterodimer with HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L- methionine as methyl donor (PubMed:18539146). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5- methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323).
Human | |
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Gene Name: | TRMT112 |
Uniprot: | Q9UI30 |
Entrez: | 51504 |
Belongs to: |
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TRM112 family |
HSPC152; HSPC170; TRM112; TRM112-like protein; TRMT11-2; tRNA methyltransferase 11-2 homolog (S. cerevisiae); tRNA methyltransferase 112 homolog
Mass (kDA):
14.199 kDA
Human | |
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Location: | 11q13.1 |
Sequence: | 11; NC_000011.10 (64316460..64318596, complement) |
Nucleus, nucleoplasm. Cytoplasm, perinuclear region. Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604).
PMID: 18539146 by Figaro S., et al. HemK2 protein, encoded on human chromosome 21, methylates translation termination factor eRF1.
PMID: 20308323 by Fu D., et al. Human AlkB homolog ABH8 is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival.