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TRIP10 Antibodies
AND TRIP10 ELISA kits, TRIP10 Proteins
Many biological assays use antibodies to detect TRIP10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIP10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIP10 antibodies...
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TRIP10 Overview
Facts about Cdc42-interacting protein 4.
Cdc42-interacting protein 4 (TRIP10)
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis.
Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruitment WASL/N- WASP that in turn activates the Arp2/3 complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | TRIP10 |
| Uniprot: | Q15642 |
| Entrez: | 9322 |
Family
| Belongs to: |
|---|
| FNBP1 family |
Alternative Names
cdc42-interacting protein 4; CIP4STOT; HSTP; Protein Felic; Salt tolerant protein; salt tolerator; STPTRIP-10; thyroid hormone receptor interactor 10; thyroid receptor interacting protein 10; Thyroid receptor-interacting protein 10; TR-interacting protein 10
Molecular Weight
Mass (kDA):
68.352 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.3 |
| Sequence: | 19; NC_000019.10 (6739680..6751530) |
Tissue Specificity
Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.; [Isoform 5]: Cytoplasm, perinuclear region.
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Wiskott-aldrich Syndrome
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Mammary Neoplasms
- Cell Transformation, Neoplastic
- Hypertensive Disease
- Malignant Neoplasm Of Liver
- Carcinoma
Interacting Proteins
- ARHGAP17
- DAAM1
- FASLG
- Inpp5d
- RHOJ
- SH3BP1
- SMARCE1
- TINF2
- WASF1
Pathways
- Transport
- Endocytosis
- Dna Methylation
- Localization
- Methylation
- Clathrin-mediated Endocytosis
- Membrane Tubulation
- Cation Transport
- Rna Interference
- Cell Migration
- Cell Cycle
- Glucose Transport
- Membrane Invagination
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIP10
bosterbio.com/bosterbio-gene-info-cards/TRIP10
References
PMID: 9210375 by Aspenstroem P.; A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton.
PMID: 12054674 by Wang L., et al. Identification and genetic analysis of human and mouse activated Cdc42 interacting protein-4 isoforms.