TRIOBP Antibodies

AND TRIOBP ELISA kits, TRIOBP Proteins

Many biological assays use antibodies to detect TRIOBP, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIOBP in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIOBP antibodies...

We validate the specificity of these antibodies to TRIOBP by testing them on tissues known to express TRIOBP positively and negatively. Browse below to find the TRIOBP antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIOBP Infographic by Boster Bio

All TRIOBP Products

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Product

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Specificity

Applications

Price

Anti-TRIOBP Antibody

Human, Mouse

IHC, WB

$405
Cat # A05614
100ul

TRIOBP (NM_138632) Human Over-expression Lysate

Human

$960
Cat # LS011078
100 µg

TRIOBP Overview

Facts about TRIO and F-actin-binding protein.

TRIOBP 3D structure. Source: alphafold

TRIO and F-actin-binding protein (TRIOBP)

May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers.

May also act as a linker protein to recruit proteins needed for F-actin formation and turnover. .

Gene Information

Human
Gene Name:	TRIOBP
Uniprot:	Q9H2D6
Entrez:	11078

Family

Belongs to:

No superfamily

Alternative Names

FLJ39315; TARA; TRIO and F-actin binding protein; TRIO and F-actin-binding protein

Molecular Weight

Mass (kDA):
261.376 kDA

Genomic Context


Human

Location:	22q13.1
Sequence:	22; NC_000022.11 (37697048..37776556)

Tissue Specificity

Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues.

Subcellular Localizations

Nucleus. Cytoplasm, cytoskeleton. Localized to F-actin in a periodic pattern.; [Isoform 1]: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody.

Diseases

Complete Hearing Loss
Malignant Neoplasms
Primary Neoplasm
Tissue Adhesions
Carcinoma
Neoplasms
Neoplasm Recurrence, Local
Neoplasm Metastasis
Malignant Squamous Cell Neoplasm
Lung Neoplasms
Cytopathic Effect
Deafness Congenital
Usher Syndrome, Type I

Malignant Neoplasm Of Esophagus
Malignant Neoplasm Of Lung
Carcinogenesis
Usher Syndrome
Large Cell Lung Carcinoma
Carcinoma, Large Cell
Mammary Neoplasms

Pathways

Cell Cycle
Cell Migration
Mitosis
Localization
Cell Growth
Actin Cytoskeleton Reorganization
Cell Proliferation
Hematopoietic Stem Cell Differentiation
Stem Cell Differentiation
Aging
Immune Response
Chromosome Segregation
Anaphase

Cytokinesis
Methylation
Tissue Development
Spindle Checkpoint
Axon Guidance
Cell Motility
Stem Cell Proliferation

PTMs

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIOBP

References

PMID: 11148140 by Seipel K., et al. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization.

PMID: 16385457 by Riazuddin S., et al. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.