TRIM63 Antibodies

AND TRIM63 ELISA kits, TRIM63 Proteins

Many biological assays use antibodies to detect TRIM63, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM63 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM63 antibodies...

We validate the specificity of these antibodies to TRIM63 by testing them on tissues known to express TRIM63 positively and negatively. Browse below to find the TRIM63 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIM63 Infographic by Boster Bio

All TRIM63 Products

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Product

Figures

Specificity

Applications

Price

Anti-TRIM63 Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$405
Cat # A02016
100ul

Anti-MURF1/TRIM63 Antibody Picoband®

Human, Monkey

ELISA, WB

$370
Cat # A02016-2
100 μg/vial

MURF1 (TRIM63) (NM_032588) Human Over-expression Lysate

Human

$628
Cat # LS084676
100 µg

TRIM63 Overview

Facts about E3 ubiquitin-protein ligase TRIM63.

TRIM63 3D structure. Source: alphafold

E3 ubiquitin-protein ligase TRIM63 (TRIM63)

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH.

Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to present other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation.

Gene Information

Human
Gene Name:	TRIM63
Uniprot:	Q969Q1
Entrez:	84676

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2.-; IRF; IRFMURF2; Iris RING finger protein; MuRF1; MuRF-1; muscle specific ring finger protein 2; Muscle-specific RING finger protein 1; RING finger protein 28FLJ32380; RNF28; RNF28E3 ubiquitin-protein ligase TRIM63; SMRZ; SMRZMURF-1; Striated muscle RING zinc finger protein; TRIM63; tripartite motif containing 63; tripartite motif-containing 63; Tripartite motif-containing protein 63

Molecular Weight

Mass (kDA):
40.248 kDA

Genomic Context


Human

Location:	1p36.11
Sequence:	1; NC_000001.11 (26051301..26067633, complement)

Tissue Specificity

Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.

Subcellular Localizations

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle.

Diseases

Muscular Atrophy
Atrophy
Hypertrophy
Cachexia
Heart Failure
Weakness
Malignant Neoplasms
Neoplasms
Systemic Infection
Myopathy
Diabetes Mellitus
Cardiac Hypertrophy

Inflammation
Chronic Obstructive Airway Disease
Dystrophy
Wasting Syndrome
Arthritis
Disuse Muscle Atrophy

Interacting Proteins

CCAR1
DCAF8
EEF1G
GFM1
MRPL41

MYOZ1
TTN
USP13

Pathways

Muscle Atrophy
Proteolysis
Skeletal Muscle Atrophy
Aging
Muscle Hypertrophy
Skeletal Muscle Hypertrophy
Autophagy
Translation
Conjugation
Cell Proliferation
Regeneration
Pathogenesis
Localization

Transport
Satellite Cell Proliferation
Protein Ubiquitination
Cell Adhesion
Cell Activation
Cell Differentiation
Myoblast Differentiation

PTMs

Phosphorylation
Ubiquitination
Cleavage

Oxidation
Acetylation
Ubiquitinylation

Glutamylation

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM63

References

PMID: 11243782 by Centner T., et al. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain.

PMID: 12107412 by Wistow G., et al. Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium.