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- Table of Contents
Facts about E3 ubiquitin-protein ligase TRIM56.
Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES.
Human | |
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Gene Name: | TRIM56 |
Uniprot: | Q9BRZ2 |
Entrez: | 81844 |
Belongs to: |
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TRIM/RBCC family |
DKFZp667O116; E3 ubiquitin-protein ligase TRIM56; EC 6.3.2.-; RING finger protein 109; RNF109FLJ35608; tripartite motif containing 56; tripartite motif-containing 56; Tripartite motif-containing protein 56
Mass (kDA):
81.488 kDA
Human | |
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Location: | 7q22.1 |
Sequence: | 7; NC_000007.14 (101085424..101097967) |
Widely expressed (at protein level).
Cytoplasm.
PMID: 21289118 by Wang J., et al. TRIM56 is a virus- and interferon-inducible E3 ubiquitin ligase that restricts pestivirus infection.
PMID: 22948160 by Shen Y., et al. TRIM56 is an essential component of the TLR3 antiviral signaling pathway.