TRIM23 Antibodies

AND TRIM23 ELISA kits, TRIM23 Proteins

Many biological assays use antibodies to detect TRIM23, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TRIM23 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TRIM23 antibodies...

We validate the specificity of these antibodies to TRIM23 by testing them on tissues known to express TRIM23 positively and negatively. Browse below to find the TRIM23 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TRIM23 Infographic by Boster Bio

All TRIM23 Products

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Anti-TRIM23 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A10305
100ul

TRIM23 Overview

Facts about E3 ubiquitin-protein ligase TRIM23.

TRIM23 3D structure. Source: alphafold

E3 ubiquitin-protein ligase TRIM23 (TRIM23)

Acts as an E3 ubiquitin-protein ligase.
Plays an important role in autophagy activation during viral infection.

Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and capacity to phosphorylate the selective autophagy receptor SQSTM1. So as to accomplish this purpose, TRIM23 mediates'Lys-27'-connected auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090).

Gene Information

Human
Gene Name:	TRIM23
Uniprot:	P36406
Entrez:	373

Family

Belongs to:

No superfamily

Alternative Names

ADP-ribosylation factor domain protein 1, 64kDa; ADP-ribosylation factor domain-containing protein 1; ARD1GTP-binding protein ARD-1; ARF domain protein 1; ARFD1; E3 ubiquitin-protein ligase TRIM23; EC 6.3.2.-; RNF46RING finger protein 46; tripartite motif containing 23; tripartite motif protein TRIM23; tripartite motif-containing 23; Tripartite motif-containing protein 23

Molecular Weight

Mass (kDA):
64.067 kDA

Genomic Context


Human

Location:	5q12.3
Sequence:	5; NC_000005.10 (65589690..65624333, complement)

Subcellular Localizations

Cytoplasm. Endomembrane system. Golgi apparatus membrane. Lysosome membrane. Membrane-associated with the Golgi complex and lysosomal structures.

Diseases

Cholera
Virus Diseases
Malignant Neoplasms
Neoplasms
Infective Disorder
Neuroblastoma
Malignant Squamous Cell Neoplasm
Tumor Progression
Von Hippel-lindau Syndrome
Head And Neck Carcinoma
Hypoxia

Diabetes Mellitus
Carcinoma
Cytomegalovirus Infections
Shwachman Syndrome
Nephrogenic Diabetes Insipidus

Pathways

Transport
Dna Replication
Translation
Conjugation

PTMs

Ribosylation
Ubiquitinylation

Ubiquitination
Myristoylation

Research Areas

Signal Transduction
Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TRIM23

References

PMID: 8473324 by Mishima K., et al. ARD 1, a 64-kDa guanine nucleotide-binding protein with a carboxyl- terminal ADP-ribosylation factor domain.

PMID: 11331580 by Reymond A., et al. The tripartite motif family identifies cell compartments.