Tripartite motif-containing protein 16 (TRIM16)

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress- induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by regulating the ubiquitination levels and thus stability of NRF2.

Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. Consequently, protects the cell against oxidative stress-induced cell death as a result of endomembrane damage.