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- Table of Contents
Facts about T-cell receptor-associated transmembrane adapter 1.
Human | |
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Gene Name: | TRAT1 |
Uniprot: | Q6PIZ9 |
Entrez: | 50852 |
Belongs to: |
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No superfamily |
pp29/30; T cell receptor associated transmembrane adaptor 1; T cell receptor interacting molecule; T-cell receptor interacting molecule; T-cell receptor-associated transmembrane adapter 1; T-cell receptor-interacting molecule; TCRIM; TRAT1; TRIM; TRIMHSPC062
Mass (kDA):
21.211 kDA
Human | |
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Location: | 3q13.13 |
Sequence: | 3; NC_000003.12 (108822786..108855005) |
Strongly expressed in thymus, and to a lesser extent in spleen, lymph node and peripheral blood lymphocytes. Present in T-cells and NK cells, but not B-cells (at protein level).
Cell membrane; Single-pass type III membrane protein.
PMID: 9687533 by Bruyns E., et al. T cell receptor (TCR) interacting molecule (TRIM), a novel disulfide- linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membrane.
PMID: 11390434 by Kirchgessner H., et al. The transmembrane adaptor protein TRIM regulates T-cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.