TNF receptor-associated factor 2 (TRAF2)

Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and boosts'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1.

Is a vital constituent of many E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain.