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- Table of Contents
Facts about Tumor necrosis factor receptor type 1-associated DEATH domain protein.
Overexpression of TRADD leads to two important TNF-induced responses, apoptosis and activation of NF-kappa-B. .
Human | |
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Gene Name: | TRADD |
Uniprot: | Q15628 |
Entrez: | 8717 |
Belongs to: |
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No superfamily |
MGC11078; TNFRSF1A-associated via death domainTNFR1-associated DEATH domain protein; TRADD; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
Mass (kDA):
34.247 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (67154185..67159909, complement) |
Found in all examined tissues.
Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Shuttles between the cytoplasm and the nucleus.
PMID: 7758105 by Hsu H., et al. The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation.
PMID: 8612133 by Hsu H., et al. TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.