Tropomyosin alpha-1 chain Antibodies

AND TPM1 ELISA kits, Tropomyosin alpha-1 chain Proteins

Many biological assays use antibodies to detect Tropomyosin alpha-1 chain, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tropomyosin alpha-1 chain in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tropomyosin alpha-1 chain antibodies...

We validate the specificity of these antibodies to Tropomyosin alpha-1 chain by testing them on tissues known to express TPM1 positively and negatively. Browse below to find the TPM1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TPM1 Infographic by Boster Bio

All TPM1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Tropomyosin(36/39 kDa) Tpm1 Antibody (Monoclonal, TM31)

7 Q&As

Chicken, Human, Mouse, Rat

$370
Cat # MA1095
100 μg/vial

Anti-Tropomyosin Alpha TPM1 Antibody

Human, Mouse, Rat, Zebrafish

IF, ICC, WB

$405
Cat # A01591-1
100ul

Anti-Tropomyosin 1 TPM1 Antibody

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$405
Cat # A01591-2
100ul

TPM1 (NM_000366) Human Recombinant Protein

$1062
Cat # PROTP09493
20 µg

Anti-Tropomyosin 1 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M01591
100 μl/vial

TPM1 (NM_001018005) Human Over-expression Lysate

Human

$628
Cat # LS007168
100 µg

TPM1 Overview

Facts about Tropomyosin alpha-1 chain.

TPM1 3D structure. Source: alphafold

Tropomyosin alpha-1 chain (TPM1)

Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982).

Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Gene Information

Human
Gene Name:	TPM1
Uniprot:	P09493
Entrez:	7168

Family

Belongs to:

tropomyosin family

Alternative Names

alpha tropomyosin; alpha-tropomyosin; C15orf13; cardiomyopathy, hypertrophic 3; chromosome 15 open reading frame 13; CMD1Y; CMH3; HTM-alpha; sarcomeric tropomyosin kappa; TMSA; tropomyosin 1 (alpha) isoform 1; tropomyosin 1 (alpha) isoform 2; tropomyosin 1 (alpha) isoform 3; tropomyosin 1 (alpha) isoform 4; tropomyosin 1 (alpha) isoform 5; tropomyosin 1 (alpha) isoform 6; tropomyosin 1 (alpha) isoform 7; tropomyosin 1 (alpha); tropomyosin alpha-1 chain; tropomyosin-1

Molecular Weight

Mass (kDA):
32.709 kDA

Genomic Context


Human

Location:	15q22.2
Sequence:	15; NC_000015.10 (63042698..63071915)

Tissue Specificity

Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.

Subcellular Localizations

Cytoplasm, cytoskeleton. Associates with F-actin stress fibers.

Diseases

Cardiomyopathies
Hypertrophy
Hypertrophic Cardiomyopathy
Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Cardiomyopathy, Dilated
Cardiomyopathy, Hypertrophic, Familial
Heart Failure
Malignant Neoplasm Of Breast
Cardiomyopathy, Familial Idiopathic
Mammary Neoplasms

Malignant Paraganglionic Neoplasm
Sudden Cardiac Death
Carcinoma
Left Ventricular Hypertrophy
Tissue Adhesions
Neoplasm Metastasis
Neoplasm Invasiveness

Interacting Proteins

C1orf216
CAGE1
GOLGA2
IFIT3
KXD1

MAD1L1
SYCE1
TFPT
TNNT1

Pathways

Cell Proliferation
Pathogenesis
Muscle Contraction
Transport
Localization
Cytokinesis
Cell Differentiation
Cell Cycle
Cell Growth
Secretion
Cell Migration
Cell Motility
Methylation

Translation
Cell Death
Angiogenesis
Regulation Of Cytoskeleton
Response To Oxidative Stress
Mating
Cell Morphogenesis

PTMs

Phosphorylation
Acetylation
Methylation

Demethylation
Cleavage
Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TPM1

References

PMID: 3548719 by Mische S.M., et al. Relation of streptococcal M protein with human and rabbit tropomyosin: the complete amino acid sequence of human cardiac alpha tropomyosin, a highly conserved contractile protein.

PMID: 3336357 by Lin C.-S., et al. Cloning and characterization of a cDNA encoding transformation- sensitive tropomyosin isoform 3 from tumorigenic human fibroblasts.