TP53-binding protein 1 Antibodies

AND TP53BP1 ELISA kits, TP53-binding protein 1 Proteins

Many biological assays use antibodies to detect TP53-binding protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TP53-binding protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TP53-binding protein 1 antibodies...

We validate the specificity of these antibodies to TP53-binding protein 1 by testing them on tissues known to express TP53BP1 positively and negatively. Browse below to find the TP53BP1 antibody that suites your experiment. We have 8 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TP53BP1 Infographic by Boster Bio

All TP53BP1 Products

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Specificity

Applications

Price

Anti-53BP1/TP53BP1 Antibody Picoband®

17 Q&As

Human, Mouse, Rat

IHC, ICC, WB

$370
Cat # PA1976
100 μg/vial

Anti-53BP1 TP53BP1 Rabbit Monoclonal Antibody

18 Q&As

+20

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00397
100 μl

53BP1 Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$480
Cat # EKC1007
1 kit, containing one 96-well plate and all necessary reagents

53BP1 (Phospho-Ser6) Colorimetric Cell-Based ELISA Kit

Human, Mouse, Rat

ELISA

$540
Cat # EKC2183
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-53BP1 (S6) TP53BP1 Antibody

Human, Monkey, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A00397S6
100ul

Anti-Phospho-53BP1 (S25) TP53BP1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A00397S25
100ul

Anti-53BP1/TP53BP1 Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00397
100 μg/vial

Anti-TP53BP1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00397-1
100 µg/vial

TP53BP1 Overview

Facts about TP53-binding protein 1.

TP53BP1 3D structure. Source: alphafold

TP53-binding protein 1 (TP53BP1)

Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) through antibody genesis (PubMed:12364621, PubMed:22553214, PubMed:23333306, PubMed:17190600, PubMed:21144835, PubMed:28241136). Plays a vital role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214, PubMed:23727112, PubMed:23333306).

In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs websites (PubMed:28241136). Recruited to DSBs websites by recognizing and binding histone H2A monoubiquitinated at'Lys-15' (H2AK15Ub) and histone H4 dimethylated at'Lys-20' (H4K20me2), two histone marks that are found at DSBs websites (PubMed:23760478, PubMed:28241136, PubMed:17190600).

Gene Information

Human
Gene Name:	TP53BP1
Uniprot:	Q12888
Entrez:	7158

Family

Belongs to:

No superfamily

Alternative Names

53BP1; FLJ41424; MGC138366; p202; p53-binding protein 1; p53bp1; TP53BP1; tumor protein 53-binding protein, 1; tumor protein p53 binding protein 1; tumor protein p53-binding protein, 1; tumor suppressor p53-binding protein 1

Molecular Weight

Mass (kDA):
213.574 kDA

Genomic Context


Human

Location:	15q15.3
Sequence:	15; NC_000015.10 (43403061..43510640, complement)

Subcellular Localizations

Nucleus. Chromosome. Chromosome, centromere, kinetochore. Localizes to the nucleus in absence of DNA damage (PubMed:28241136). Following DNA damage, recruited to sites of DNA damage, such as double stand breaks (DSBs): recognizes and binds histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSBs sites (PubMed:23333306, PubMed:23760478, PubMed:24703952, PubMed:28241136, PubMed:17190600). Associated with kinetochores during mitosis (By similarity).