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- Table of Contents
Facts about TOX high mobility group box family member 3.
Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters.
Human | |
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Gene Name: | TOX3 |
Uniprot: | O15405 |
Entrez: | 27324 |
Belongs to: |
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No superfamily |
CAG trinucleotide repeat-containing gene F9 protein; CAGF9trinucleotide repeat containing 9; TNRC9; TOX high mobility group box family member 3; Trinucleotide repeat-containing gene 9 protein
Mass (kDA):
63.342 kDA
Human | |
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Location: | 16q12.1 |
Sequence: | 16; NC_000016.10 (52436415..52547802, complement) |
Expressed mainly in epithelial cells. Expressed in the central nervous system (CNS), in the ileum and within the brain in the frontal and occipital lobe.
Nucleus.
PMID: 9225980 by Margolis R.L., et al. cDNAs with long CAG trinucleotide repeats from human brain.
PMID: 21172805 by Dittmer S., et al. TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.