TOPORS Antibodies

AND TOPORS ELISA kits, TOPORS Proteins

Many biological assays use antibodies to detect TOPORS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TOPORS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TOPORS antibodies...

We validate the specificity of these antibodies to TOPORS by testing them on tissues known to express TOPORS positively and negatively. Browse below to find the TOPORS antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TOPORS Infographic by Boster Bio

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Anti-TOPRS TOPORS Antibody

Human, Mouse

ELISA, WB

$380
Cat # A07475
100ul

TOPORS Overview

Facts about E3 ubiquitin-protein ligase Topors.

TOPORS 3D structure. Source: alphafold

E3 ubiquitin-protein ligase Topors (TOPORS)

Functions as an E3 ubiquitin-protein ligase as Well as an E3 SUMO1-protein ligase.
Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that modulates p53/TP53 stability through ubiquitin-dependent degradation.

May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage- induced cell death through IKBKE sumoylation.

Gene Information

Human
Gene Name:	TOPORS
Uniprot:	Q9NS56
Entrez:	10210

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2.-; LUNtopoisomerase I binding, arginine/serine-rich; p53-binding protein 3; p53BP3; retinitis pigmentosa 31 (autosomal dominant); RP31; SUMO1-protein E3 ligase Topors; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; TP53BPLE3 ubiquitin-protein ligase Topors; Tumor suppressor p53-binding protein 3

Molecular Weight

Mass (kDA):
119.198 kDA

Genomic Context


Human

Location:	9p21.1
Sequence:	9; NC_000009.12 (32540544..32552628, complement)

Tissue Specificity

Expressed at highest levels in testis and at lower levels in adrenal gland, bone marrow, brain, colon, heart, kidney, liver, muscle, ovary, pancreas, placenta, prostate, skeletal muscle, skin, small intestine, spleen, stomach, testis, thymus, thyroid and uterus. Expressed in the alveolar epithelium of the lung. Expression is commonly decreased in colon adenocarcinomas and lung cancers.

Subcellular Localizations

Nucleus. Nucleus, PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.

Diseases

Malignant Neoplasms
Neoplasms
Acute Promyelocytic Leukemia
Leukemia
Retinitis Pigmentosa
Genotoxic Stress
Malignant Neoplasm Of Lung
Osteosarcoma
Genomic Instability
Atrophy
Malignant Paraganglionic Neoplasm
Cell Transformation, Neoplastic

Retinal Dystrophies
Neoplasm Metastasis
Disuse Muscle Atrophy
Malignant Neoplasm Of Breast
Werner Syndrome
Malignant Tumor Of Colon

Pathways

Localization
Cell Growth
Cell Cycle
Aging
Protein Sumoylation
Dna Repair
Conjugation
Cell Death
Regulation Of Viral Transcription
Cell Migration
Response To Camptothecin
Programmed Cell Death
Cellular Senescence

Proteolysis
Hypersensitivity
Chromosome Segregation
Anaphase
Cell Cycle Arrest
Viral Transcription
Cell Differentiation

PTMs

Sumoylation
Ubiquitination

Phosphorylation
Cleavage

Methylation

Research Areas

Zinc Finger

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TOPORS

References

PMID: 10352183 by Haluska P. Jr., et al. Interaction between human topoisomerase I and a novel RING finger/arginine-serine protein.

PMID: 11278651 by Chu D., et al. Cloning and characterization of LUN, a novel RING-finger protein that is highly expressed in lung and specifically binds to a palindromic sequence.