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- Table of Contents
Facts about Tensin-3.
EGF activates TNS4 and down-regulates TNS3 which causes capping the tail of ITGB1. Appears to be involved in mammary cell migration.
Human | |
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Gene Name: | TNS3 |
Uniprot: | Q68CZ2 |
Entrez: | 64759 |
Belongs to: |
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PTEN phosphatase protein family |
TEM6; TENS1; Tensin 3; tensin-3; Tensin-Like SH2 Domain Containing 1; Tensin-Like SH2 Domain-Containing 1; Tensin-Like SH2 Domain-Containing Protein 1; Thyroid Specific PTB Domain Protein; TPP; Tumor Endothelial Marker 6
Mass (kDA):
155.266 kDA
Human | |
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Location: | 7p12.3 |
Sequence: | 7; NC_000007.14 (47275154..47582553, complement) |
Expressed in umbilical vein endothelial cells, epithelial cells, and fibroblasts cells (at protein level). Highly expressed in thyroid, kidney and placenta. Low expression in heart, skeletal muscle, spleen, liver, and lung. Expressed in tumor endothelial cells. Expression seems to be down-regulated in thyroid tumor tissues and in anaplastic carcinomas.
Cell junction, focal adhesion.
PMID: 11559528 by Carson-Walter E.B., et al. Cell surface tumor endothelial markers are conserved in mice and humans.
PMID: 15140944 by Cui Y., et al. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3.