TNRC6C Antibodies

AND TNRC6C ELISA kits, TNRC6C Proteins

Many biological assays use antibodies to detect TNRC6C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNRC6C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNRC6C antibodies...

We validate the specificity of these antibodies to TNRC6C by testing them on tissues known to express TNRC6C positively and negatively. Browse below to find the TNRC6C antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNRC6C Infographic by Boster Bio

All TNRC6C Products

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Anti-TNRC6C Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A09089
100 µg/vial

Anti-TNRC6C Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A09089-1
100 µg/vial

TNRC6C Overview

Facts about Trinucleotide repeat-containing gene 6C protein.

TNRC6C 3D structure. Source: alphafold

Trinucleotide repeat-containing gene 6C protein (TNRC6C)

Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins.

As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4- NOT and PAN deadenylase complexes. .

Gene Information

Human
Gene Name:	TNRC6C
Uniprot:	Q9HCJ0
Entrez:	57690

Family

Belongs to:

GW182 family

Alternative Names

KIAA1582FLJ20015; trinucleotide repeat containing 6C; trinucleotide repeat-containing gene 6C protein

Molecular Weight

Mass (kDA):
175.964 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (77958853..78108835)

Diseases

Stomach Neoplasms
Malignant Neoplasm Of Stomach
Malignant Neoplasms
Mutation, Out-of-frame
Colorectal Neoplasms
Nervous System Disorder
High-frequency Microsatellite Instability
Colorectal Cancer

Microsatellite Instability
Low-frequency Microsatellite Instability

Interacting Proteins

AGO2
Ago2
CNOT1
CNOT10
CNOT2

CNOT3
CNOT6
CNOT6L
CNOT7
PABPC1

PAN2
PAN3

Pathways

Translation
Gene Silencing
Mrna Processing
Rna Interference
Localization

PTMs

Methylation

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNRC6C

References

PMID: 19716330 by Fabian M.R., et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.

PMID: 19304925 by Zipprich J.T., et al. Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.