TNK1 Antibodies

AND TNK1 ELISA kits, TNK1 Proteins

Many biological assays use antibodies to detect TNK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TNK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TNK1 antibodies...

We validate the specificity of these antibodies to TNK1 by testing them on tissues known to express TNK1 positively and negatively. Browse below to find the TNK1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TNK1 Infographic by Boster Bio

All TNK1 Products

Product

Figures

Specificity

Applications

Price

Anti-TNK1 Monoclonal Antibody

Human

ELISA, WB

$380
Cat # M08145
100ul

TNK1 (NM_003985) Human Over-expression Lysate

Human

$960
Cat # LS008711
100 µg

TNK1 Overview

Facts about Non-receptor tyrosine-protein kinase TNK1.

TNK1 3D structure. Source: alphafold

Non-receptor tyrosine-protein kinase TNK1 (TNK1)

Involved in negative regulation of cell growth. Has tumor suppressor properties.

Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and much more selectively in adult tissues and in cells of the lymphohematopoietic system.

Gene Information

Human
Gene Name:	TNK1
Uniprot:	Q13470
Entrez:	8711

Family

Belongs to:

protein kinase superfamily

Alternative Names

CD38 negative kinase 1; EC 2.7.10; EC 2.7.10.2; MGC46193; non-receptor tyrosine-protein kinase TNK1; tyrosine kinase, non-receptor, 1

Molecular Weight

Mass (kDA):
72.468 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (7380559..7389964)

Tissue Specificity

Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain.

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein.

Diseases

Alzheimer's Disease
Neoplasms
Malignant Neoplasms
Lymphoma
Neoplasms, Experimental
Carcinoma
5,10-methylenetetrahydrofolate Reductase Deficiency
Cell Transformation, Neoplastic
Malignant Paraganglionic Neoplasm
Neoplasm Invasiveness
Inflammatory Response
Malignant Neoplasm Of Lung
Multiple Myeloma

Papillary Adenocarcinoma
Pancreatic Neoplasm
Papillary Thyroid Carcinoma
Malignant Neoplasm Of Pancreas
Cell Invasion
Influenza
Lung Neoplasms

Interacting Proteins

Pathways

Cell Growth
Pathogenesis
Transport
Intracellular Transport
Aging
Gluconeogenesis
Negative Regulation Of Cell Growth
Metaphase
Inflammatory Response
Cytokine Production
Sensitization

Cell Cycle
Cell Death
Regulation Of Cell Growth
Chromatin Remodeling
Autophagy
Oncogenesis

PTMs

Phosphorylation

Methylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNK1

References

PMID: 8632913 by Hoehn G.T., et al. Tnk1: a novel intracellular tyrosine kinase gene isolated from human umbilical cord blood CD34+/Lin-/CD38- stem/progenitor cells.

PMID: 10873601 by Felschow D.M., et al. Characterization of the tyrosine kinase Tnk1 and its binding with phospholipase C-gamma1.