TNFSF8 Antibodies

Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells.

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Gene Information

Human
Gene Name:	TNFSF8
Uniprot:	P32971
Entrez:	944

Family

Belongs to:
tumor necrosis factor family

Alternative Names

CD153 antigen; CD153; CD30 antigen ligand; CD30 Ligand; CD30L; CD30-L; CD30LCD30 ligand; CD30LGMGC138144; TNFSF8; tumor necrosis factor (ligand) superfamily, member 8; tumor necrosis factor ligand superfamily member 8

Molecular Weight

Mass (kDA):
26.017 kDA

Genomic Context

Human
Location:	9q32-q33.1
Sequence:	9; NC_000009.12 (114893343..114930674, complement)

Subcellular Localizations

Membrane; Single-pass type II membrane protein.

Diseases

• Lymphoma
• Hodgkin Disease
• Neoplasms
• Malignant Neoplasms
• Malignant Paraganglionic Neoplasm
• Leukemia
• Ki-1+ Anaplastic Large Cell Lymphoma
• Autoimmune Reaction
• Diffuse Large B-cell Lymphoma
• Inflammation
• Lymphoma, Non-hodgkin
• Autoimmune Diseases
• Carcinoma

• Leukemia, Myelocytic, Acute
• Skin Neoplasms
• Tissue Adhesions
• Myeloid Leukemia
• Immunologic Deficiency Syndromes
• Infective Disorder
• Acute Lymphocytic Leukemia

Pathways

• Cell Death
• Cell Proliferation
• Secretion
• Cell Growth
• Pathogenesis
• Immune Response
• Cell Cycle
• T Cell Proliferation
• Cytokine Secretion
• Cell Differentiation
• Cytokine Production
• Cell Migration
• Dna Recombination

• Cell Cycle Arrest
• Induction Of Apoptosis
• B Cell Proliferation
• Stem Cell Differentiation
• Aging
• Interferon-gamma Production
• Tropism

PTMs

• Cleavage
• Phosphorylation

• Biotinylation
• Methylation

• Dephosphorylation

Research Areas

• Apoptosis
• Cancer

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TNFSF8

Boster Bio - Best Uses Of The TNFSF8 Marker

Boster Bio is a good option if you're looking for high-affinity prima antibodies. Its anti-CD30/TNFRSF8 antibody is designed for use in cellular signaling studies. We will be discussing Steven Boster’s history and his Anti-CD30/TNFRSF8 anti-CD30/TNFRSF8 anti-CD8 antibody. Continue reading to find out more! We'll also discuss the history and product credits.

Boster Bio offers high-affinity prima antibodies

Researchers have been successful in developing novel antigen specific antibody fragments that can be used to target and study cell surfaces proteins. These antibodies are designed for use with small molecular compounds, cell surface proteins, and complexes. Boster Bio provides high-affinity primary antibodies that are highly specific against the TNFSF8 protein. Researchers can analyze samples with the help of these antibody fragments. They can determine the amount binding and lysis of specific proteins in cells.

The availability of a wide variety of primary antibodies against this marker is made possible by the fact that these molecules can be highly variable. Substitution mutations can alter the binding affinity of FcRn to Fc domains. IgG1 and IgG2 molecules, or IgG3 molecules can be included in the IgG Subclass. DHS may also be included in antibody Fc domains.

History of Steven Boster

You're in the right place if you are interested in Steve Boster’s history. There is a wealth information online about him including his current address, past addresses, cell phone numbers and email addresses as well as information about his known relatives. You can also search his name and state to narrow your search. There are many historic landmarks connected to Steven Boster.

Steve Boster was a Joliet native. He was a Army veteran and was a long-standing manager of retail sales. Steve Boster was also a member of the Concordia Hall of Staunton. He is survived by his 2 daughters, Natosha and Crystal Peck, his 6 grandchildren and 4 brothers (Sandy Blanton & Jack Boster), as well as his sister Tammy and his nieces & nephews.

Boster's anti CD30/TNFRSF8 antibodies

Boster bio Anti CD30/TNFRSF8 antibody (human recombinant protein) is a T322-K595-alpha amino acid sequence. It was tested with positive and negative samples from multiple research facilities to ensure a high level affinity and specificity. It is supplied with 5 mg BSA for in-house storage and is guaranteed for one year.

The anatomical location of CD30 /TNFRSF8 antibody immunohistochemically stained varies greatly. It is found in the appendix, germinal center tonsil cells, and non-germinal lymph node cells. Different staining patterns can be seen in different patients. Certain diseases may alter the patterns.

The CD30/TNFRSF8 glycoprotein is a single chain glycoprotein, approximately 90 kDa. It is converted by the Golgi complex to a membrane-bound and phosphorylated state. Anaplastic large cell lymphomas usually express CD30/TNFRSF8 as well as a portion of activated cells. About one third of lymphomas are Ki-1-positive, but lack the leukocyte common antibody (CD45).

The most useful antiTNFRSF8 antibodies recognize a wide range of cell surface antigens. The most common ones are E6 and E7 from the HPV and Epstein-Barr virus. These antibodies can be used in many different areas and have multiple uses. These antibodies are becoming more popular in diagnostic applications.

This monoclonal antibody detects the TNFSF8 marker in in vivo tumors as well as blood cells. It combines the IL-15 signal peptide and IL-2 signal peptide to produce the most efficient anti-tumor effect. The fusion is most effective when combined with other TNFSF8 antibodies, including IL-2 signal peptides.

CD19b–CD123 cCAR t-cells have a remarkable capability to target the MOLM13 or REH cell lines. They are anti-leukemic against these cell types. These experiments have shown that these cCAR T-cells can efficiently attack leukemic cells, as well as other types of cells.