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- Table of Contents
Facts about Sialic acid-binding Ig-like lectin 6.
The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. .
Human | |
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Gene Name: | SIGLEC6 |
Uniprot: | O43699 |
Entrez: | 946 |
Belongs to: |
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immunoglobulin superfamily |
CD327 antigen; CD327; CD33 antigen-like 1; CD33L1; CD33L1OBBP1CD327; CD33L2; CD33LCDW327; CDw327; OB-BP1; Obesity-binding protein 1; sialic acid binding Ig-like lectin 6; sialic acid-binding Ig-like lectin 6; Siglec6; Siglec-6
Mass (kDA):
49.913 kDA
Human | |
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Location: | 19q13.41 |
Sequence: | 19; NC_000019.10 (51517819..51531803, complement) |
Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
PMID: 9465907 by Takei Y., et al. Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta.
PMID: 10428856 by Patel N., et al. OB-BP1/Siglec-6. A leptin- and sialic acid-binding protein of the immunoglobulin superfamily.