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Facts about Tumor necrosis factor ligand superfamily member 13.
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA.
Plays a role in the regulation of tumor cell growth.May be involved in monocyte/macrophage-mediated immunological processes. .
Human | |
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Gene Name: | TNFSF13 |
Uniprot: | O75888 |
Entrez: | 8741 |
Belongs to: |
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tumor necrosis factor family |
A proliferation-inducing ligand; APRIL; APRILFLJ57090; CD256 antigen; CD256; TALL2; TALL-2; TNF- and APOL-related leukocyte expressed ligand 2; TNF-related death ligand 1; TNFSF13; TRDL1; TRDL-1; tumor necrosis factor (ligand) superfamily, member 13; tumor necrosis factor ligand superfamily member 13; tumor necrosis factor-like protein ZTNF2; tumor necrosis factor-related death ligand-1; ZTNF2
Mass (kDA):
27.433 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7558292..7561608) |
Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Secreted.
PMID: 9743536 by Hahne M., et al. APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
PMID: 10331498 by Shu H.-B., et al. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens.
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