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Tmprss6 Antibodies
AND Tmprss6 ELISA kits, Tmprss6 Proteins
Many biological assays use antibodies to detect Tmprss6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tmprss6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tmprss6 antibodies...
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Tmprss6 Infographic by Boster Bio
All Tmprss6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A02093-1
100 μg/vial
Cat # A02093-1
100 μg/vial
Tmprss6 Overview
Facts about Transmembrane protease serine 6.
Transmembrane protease serine 6 (Tmprss6)
Serine protease which hydrolyzes a range of proteins such as type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency.
May play a technical role in matrix remodeling processes in liver. Throughout the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Tmprss6 |
| Uniprot: | Q9DBI0 |
| Entrez: | 71753 |
Family
| Belongs to: |
|---|
| peptidase S1 family |
Alternative Names
EC 3.4.21; EC 3.4.21.-; FLJ30744; IRIDA; Matriptase-2; membrane-bound mosaic serine proteinase matriptase-2; transmembrane protease serine 6; transmembrane protease, serine 6; type II transmembrane serine protease 6
Molecular Weight
Mass (kDA):
90.978 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 15|15 E1 |
| Sequence: | 15; |
Tissue Specificity
Expressed at highest levels in adult mice liver, kidney and uterus. Also strongly expressed within the nasal cavity by olfactory epithelial cells. A weak, but detectable, signal in adult mice tissues analyzed including brain, lung, heart, kidney, spleen, muscle, intestine, thymus and pancreas. No signal in residual embryonic yolk sac, developing kidney tubules or in embryonic tissues analyzed including lung, heart, gastrointestinal tract and epithelium of the oral cavity.
Diseases
- Anemia
- Iron Deficiency
- Iron Deficiency Anemia
- Deficiency Anaemia
- Iron Overload
- Microcytic Anemia
- Inflammation
- Hypoxia
- Iron Metabolism Disorders
- Hemochromatosis
- Hereditary Hemochromatosis
- Malignant Neoplasms
- Microcytic Hypochromic Anemia (disorder)
Pathways
- Transport
- Pathogenesis
- Localization
- Inflammatory Response
- Reverse Transcription
- Translation
- Regulation Of Signal Transduction
- Aging
- Endocytosis
PTMs
- Cleavage
Research Areas
- Angiogenesis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Tmprss6
bosterbio.com/bosterbio-gene-info-cards/Tmprss6
References
PMID: 12744720 by Hooper J.D., et al. Mouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissues.
PMID: 18451267 by Du X., et al. The serine protease TMPRSS6 is required to sense iron deficiency.