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- Table of Contents
Facts about Transmembrane protease serine 3.
Activates ENaC (in vitro). .
Human | |
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Gene Name: | TMPRSS3 |
Uniprot: | P57727 |
Entrez: | 64699 |
Belongs to: |
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peptidase S1 family |
DFNB10; DFNB8; EC 3.4.21; EC 3.4.21.-; gene similar to transmembrane serine protease10ECHOS1Serine protease TADG-12; serine protease TADG12; TADG12; transmembrane protease serine 3; transmembrane protease, serine 3; Tumor-associated differentially-expressed gene 12 protein
Mass (kDA):
49.405 kDA
Human | |
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Location: | 21q22.3 |
Sequence: | 21; NC_000021.9 (42371837..42396052, complement) |
Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
PMID: 11068177 by Underwood L.J., et al. Ovarian tumor cells express a novel multi-domain cell surface serine protease.
PMID: 11137999 by Scott H.S., et al. Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness.