Tropomodulin-1 Antibodies

AND TMOD1 ELISA kits, Tropomodulin-1 Proteins

Many biological assays use antibodies to detect Tropomodulin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Tropomodulin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Tropomodulin-1 antibodies...

We validate the specificity of these antibodies to Tropomodulin-1 by testing them on tissues known to express TMOD1 positively and negatively. Browse below to find the TMOD1 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMOD1 Infographic by Boster Bio

All TMOD1 Products

Product

Figures

Specificity

Applications

Price

Anti-Tropomodulin-1 TMOD1 Antibody

Human, Mouse, Rat

$405
Cat # A04701
100ul

Tropomodulin 1 (TMOD1) (NM_003275) Human Recombinant Protein

$1249
Cat # PROTP28289
20 µg

Anti-Tropomodulin 1 (TMOD1) Mouse Monoclonal Antibody [Clone ID: OTI1F2]

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M04701
100 µl

Anti-Tropomodulin 1 (TMOD1) Mouse Monoclonal Antibody [Clone ID: OTI2C2]

Human, Monkey, Mouse, Rat

IF, IHC, WB

$523
Cat # M04701-1
100 µl

Tropomodulin 1 (TMOD1) (NM_003275) Human Over-expression Lysate

Human

$628
Cat # LS007111
100 µg

TMOD1 Overview

Facts about Tropomodulin-1.

TMOD1 3D structure. Source: alphafold

Tropomodulin-1 (TMOD1)

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the brief actin protofilament, which in turn defines the geometry of the membrane skeleton.

May play an essential role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. .

Gene Information

Human
Gene Name:	TMOD1
Uniprot:	P28289
Entrez:	7111

Family

Belongs to:

tropomodulin family

Alternative Names

D9S57E; Erythrocyte tropomodulin; E-Tmod; e-tropomodulin; TMODETMOD; tropomodulin 1; tropomodulin-1

Molecular Weight

Mass (kDA):
40.569 kDA

Genomic Context


Human

Location:	9q22.33
Sequence:	9; NC_000009.12 (97501180..97601743)

Tissue Specificity

Highly expressed in the erythrocyte, heart and skeletal muscle.

Subcellular Localizations

Cytoplasm, cytoskeleton. In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574).

Diseases

Cardiomyopathies
Cardiomyopathy, Dilated
Hypertrophy
Tissue Adhesions
Hypertrophic Cardiomyopathy
Graves Disease
Cardiac Hypertrophy
Thyroid Diseases
Myopathy
Heart Failure
Heart Diseases
Congenital Heart Defects

Thyroid Associated Opthalmopathies
Sclerosis
Primary Lateral Sclerosis
Inflammatory Bowel Diseases
Cardiomyopathy, Hypertrophic, Familial
Amyotrophic Lateral Sclerosis
Myopathies, Nemaline

Pathways

Localization
Muscle Contraction
Cell Differentiation
Actin Filament Capping
Actin Filament Organization
Nuclear Export
Myofibril Assembly
Actin Filament Polymerization
Lens Fiber Cell Differentiation
Pathogenesis
Cell Adhesion
Cell Migration
Aging

Proteolysis
Cell Fate Determination
Vasculogenesis
Inflammatory Response
Cytokinesis
Cell Maturation
Cell Division

PTMs

Phosphorylation
Reduction

Cleavage
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMOD1

References

PMID: 1370827 by Sung L.A., et al. Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein.

PMID: 11054557 by Chu X., et al. Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments.