Meckelin Antibodies

AND TMEM67 ELISA kits, Meckelin Proteins

Many biological assays use antibodies to detect Meckelin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Meckelin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Meckelin antibodies...

We validate the specificity of these antibodies to Meckelin by testing them on tissues known to express TMEM67 positively and negatively. Browse below to find the TMEM67 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TMEM67 Infographic by Boster Bio

All TMEM67 Products

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Anti-Meckelin Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M04691
100 μl/vial

TMEM67 Overview

Facts about Meckelin.

TMEM67 3D structure. Source: alphafold

Meckelin (TMEM67)

Required for ciliary structure and function. Part of this tectonic-like complex which is required for tissue-specific ciliogenesis and might regulate ciliary membrane composition (By similarity).

Involved in centrosome migration into the apical cell surface through early ciliogenesis. Involved in the regulation of cilia length and appropriate amount through the control of centrosome duplication.

Gene Information

Human
Gene Name:	TMEM67
Uniprot:	Q5HYA8
Entrez:	91147

Family

Belongs to:

No superfamily

Alternative Names

meckel syndrome type 3 protein; Meckelin; MGC26979; TNEM67; transmembrane protein 67

Molecular Weight

Mass (kDA):
111.745 kDA

Genomic Context


Human

Location:	8q22.1
Sequence:	8; NC_000008.11 (93754844..93832653)

Tissue Specificity

Widely expressed in adult and fetal tissues. Expressed at higher level in spinal cord.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Localizes at the transition zone, a region between the basal body and the ciliary axoneme (PubMed:22121117).

Diseases

Meckel-gruber Syndrome
Familial Aplasia Of The Vermis
Congenital Cerebral Hernia
Polydactyly
Dysplasia
Cystic Kidney Diseases
Nervousness
Nephronophthisis
Ciliary Motility Disorders
Polycystic Kidney Diseases
Kidney Diseases
Fibrosis

Occipital Encephalocele
Ataxia
Hepatic Fibrosis
Dystrophy
Muscle Hypotonia
Congenital Neurologic Anomalies
Liver Diseases

Pathways

Localization
Pathogenesis
Transport
Gastrulation
Brain Development
Establishment Of Cell Polarity
Glycosylation
Cognition
Centrosome Duplication

Phototransduction
Sensory Perception
Tissue Homeostasis

PTMs

Glycoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TMEM67

References

PMID: 17185389 by Dawe H.R., et al. The Meckel-Gruber syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation.

PMID: 19515853 by Tammachote R., et al. Ciliary and centrosomal defects associated with mutation and depletion of the Meckel syndrome genes MKS1 and MKS3.