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- Table of Contents
Facts about Bax inhibitor 1.
Modulates ER calcium homeostasis by acting as a calcium-leak station (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient depletion, and reduces cell survival during puberty (By similarity).
Human | |
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Gene Name: | TMBIM6 |
Uniprot: | P55061 |
Entrez: | 7009 |
Belongs to: |
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BI1 family |
BAXI1; BI1; BI-1Transmembrane BAX inhibitor motif-containing protein 6; TEGTbax inhibitor 1; testis enhanced gene transcript; Testis-enhanced gene transcript protein; transmembrane BAX inhibitor motif containing 6
Mass (kDA):
26.538 kDA
Human | |
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Location: | 12q13.12 |
Sequence: | 12; NC_000012.12 (49741557..49764934) |
Highly abundant in testis.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PMID: 8530040 by Walter L., et al. Identification of a novel conserved human gene, TEGT.
PMID: 9660918 by Xu Q., et al. Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
*More publications can be found for each product on its corresponding product page