Toll-like receptor 2 Antibodies

AND TLR2 ELISA kits, Toll-like receptor 2 Proteins

Many biological assays use antibodies to detect Toll-like receptor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Toll-like receptor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Toll-like receptor 2 antibodies...

We validate the specificity of these antibodies to Toll-like receptor 2 by testing them on tissues known to express TLR2 positively and negatively. Browse below to find the TLR2 antibody that suites your experiment. We have 11 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: NR2E1

TLR2 Infographic by Boster Bio

All TLR2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human TLR2/Toll-like receptor 2 ELISA Kit PicoKine®

2 Citations 9 Q&As

Human

ELISA

$499
Cat # EK0906
96 wells/kit, with removable strips.

Mouse TLR2/Toll-like receptor 2 ELISA Kit PicoKine®

1 Citations 9 Q&As

Mouse

ELISA

$499
Cat # EK1130
96 wells/kit, with removable strips.

Anti-TLR2 Antibody Picoband®

16 Citations 15 Q&As

Human

$370
Cat # A00131
100 μg/vial

Anti-TLR2 Rabbit Monoclonal Antibody

5 Citations 17 Q&As

Human, Mouse, Rat

$370
Cat # M00131
100 μl

Anti-Toll-like receptor 2 TLR2 Antibody

1 Citations

Human, Mouse

ELISA, IF, IHC-P, WB

$449
Cat # A00131-1
0.1 mg

Anti-Toll-like receptor 2 TLR2 Antibody

1 Citations

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A00131-3
100ul

Human TLR2 Recombinant Protein

SDS-PAGE

$350
Cat # PROTO60603
Starting from 10ug

Mouse TLR2 Recombinant Protein

SDS-PAGE

$350
Cat # PROTQ9QUN7
Starting from 10ug

Anti-TLR2 Antibody

1 Citations

Human

$299
Cat # M00131-1
50 µl

TLR2 (NM_003264) Human Over-expression Lysate

Human

$628
Cat # LS007097
100 µg

Anti-Tlr2 Antibody Picoband®

Mouse

ELISA, WB

$370
Cat # A00131-4
100 µg/vial

TLR2 Overview

Facts about Toll-like receptor 2.

TLR2 3D structure. Source: alphafold

Toll-like receptor 2 (TLR2)

Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651).

Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996).

Gene Information

Human
Gene Name:	TLR2
Uniprot:	O60603
Entrez:	7097

Family

Belongs to:

Toll-like receptor family

Alternative Names

CD282 antigen; CD282; TIL4CD282; TLR2; toll/interleukin 1 receptor-like 4; Toll/interleukin-1 receptor-like protein 4; toll-like receptor 2

Molecular Weight

Mass (kDA):
89.838 kDA

Genomic Context


Human

Location:	4q31.3
Sequence:	4; NC_000004.12 (153684080..153710643)

Tissue Specificity

Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to diacylated lipoproteins, TLR2:TLR6 heterodimers are recruited in lipid rafts, this recruitment determines the intracellular targeting to the Golgi apparatus. Triacylated lipoproteins induce the same mechanism for TLR2:TLR1 heterodimers.

Diseases

Inflammation
Innate Immune Response
Infective Disorder
Inflammatory Response
Pneumonia
Bacterial Infections
Tuberculosis
Systemic Infection
Malignant Neoplasms
Atherosclerosis
Neoplasms
Arthritis
Tissue Adhesions

Autoimmune Reaction
Virus Diseases
Asthma
Colitis
Hepatitis
Cell Invasion
Periodontitis

Interacting Proteins

CXCR4
EGFR
MYD88
TLR1
TLR10

TLR6

Pathways

Immune Response
Secretion
Cytokine Production
Pathogenesis
Inflammatory Response
Innate Immune Response
Cell Activation
Phagocytosis
Virulence
Cytokine Secretion
Cell Proliferation
Cell Death
Macrophage Activation

Adaptive Immune Response
Chemokine Production
Localization
Sensitization
Reverse Transcription
Chemotaxis
T Cell Proliferation

PTMs

Phosphorylation
Methylation
Cleavage
Acylation
Acetylation
Oxidation
Ubiquitination
Glycosylation
Dephosphorylation
Biotinylation

Reduction
Deacetylation
Nitration
Palmitoylation
Deglycosylation
Myristoylation
Demethylation
Nitrosylation
Phosphorothioation
Hydroxylation

Research Areas

Immunology
Innate Immunity
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TLR2

References

PMID: 9596645 by Chaudhary P.M., et al. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.

PMID: 9435236 by Rock F.L., et al. A family of human receptors structurally related to Drosophila Toll.

19 Publications of Boster Toll-like receptor 2 Antibodies & ELISA Kits

PubMed ID: 10.3892/ol.2014.2621, Upregulation of Toll‑like receptor 2 expression in colorectal cancer infected...
PubMed ID: 10.3892/mmr.2017.8010, HuR induces inflammatory responses in HUVECs and murine sepsis via binding to HM...
PubMed ID: 10.3389/fncel.2017.00099, Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/R...
PubMed ID: 10.1186/1743-422X-10-40, A novel DNA vaccine expressing the Ag85A-HA2 fusion protein provides protection ...
PubMed ID: 10.1128/AEM.01636-21, Protective Effects of Selenium Nanoparticle-Enriched Lactococcus lactis NZ9000 a...
PubMed ID: 10.1111/jphp.12402, Shikonin inhibits the cell viability, adhesion, invasion and migration of the hu...
PubMed ID: 10.1038/s41467-021-25340-w, Oral immune dysfunction is associated with the expansion of FOXP3+PD-1+Amphiregu...
PubMed ID: 10.1016/j.molimm.2017.08.022, Effect of lentivirus-mediated gene silencing, targeting toll-like receptor 2, on...
PubMed ID: 10.1016/j.ijbiomac.2016.05.002, Bletilla striata polysaccharide inhibits angiotensin II-induced ROS and inflamma...
PubMed ID: 10.1002/ar.23463, Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft‐Shelled Tur...
PubMed ID: 10.1002/ar.23463, Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft‐Shelled Tur...
PubMed ID: 10.1002/ar.23463, Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft‐Shelled Tur...
PubMed ID: 31857223, Shi Y,Vistro WA,Bai X,Wu R,Chen C,Huang Y,Fazlani SA,Tarique I,Yang P,Chen Q.Eff...
PubMed ID: 32801828, Feng S,Ju L,Shao Z,Grzanna M,Jia L,Liu M.Therapeutic Effect of C-C Chemokine Rec...
PubMed ID: 27532861, Expression of TLR2/4 on Epididymal Spermatozoa of the Chinese Soft%u2010Shelled ...
PubMed ID: 27340562, Inhibition of Zymosan-Induced Inflammatory Factors Expression by ATRA Nanostruct...
PubMed ID: 23369570, A novel DNA vaccine expressing the Ag85A-HA2 fusion protein provides protection ...
PubMed ID: 24460643, Wang Y, Ge P, Yang L, Wu C, Zha H, Luo T, Zhu Y. J Neuroinflammation. 2014 Jan 2...
PubMed ID: 25435993, Li X, Qian D, Ju F, Wang B. Oncol Lett. 2015 Jan;9(1):365-370. Epub 2014 Oct 15....

*More publications can be found for each product on its corresponding product page