Transducin-like enhancer protein 4 (TLE4)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling.

The impacts of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens growth and for SIX3 transcriptional auto-repression (By similarity).