TIGIT Antibodies

AND TIGIT ELISA kits, TIGIT Proteins

Many biological assays use antibodies to detect TIGIT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TIGIT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TIGIT antibodies...

We validate the specificity of these antibodies to TIGIT by testing them on tissues known to express TIGIT positively and negatively. Browse below to find the TIGIT antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: C4orf46

TIGIT Infographic by Boster Bio

All TIGIT Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-TIGIT Monoclonal Antibody [7E5]

Human

ELISA, Flow Cytometry, IF, IHC-P, ICC

$524
Cat # M01962
0.1 mg

Anti-TIGIT Monoclonal Antibody [4A10]

Human

ELISA, Flow Cytometry, IF, IHC-P, ICC, WB

$524
Cat # M01962-1
0.1 mg

Anti-Tigit Antibody Picoband®

Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01962-1
100 μg/vial

TIGIT (NM_173799) Human Recombinant Protein

$1249
Cat # PROTQ495A1
20 µg

TIGIT (NM_173799) Human Over-expression Lysate

Human

$628
Cat # LS201633
100 µg

TIGIT Overview

Facts about T-cell immunoreceptor with Ig and ITIM domains.

TIGIT 3D structure. Source: alphafold

T-cell immunoreceptor with Ig and ITIM domains (TIGIT)

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and inhibits T-cell activation by promoting the creation of mature immunoregulatory dendritic cells. .

Gene Information

Human
Gene Name:	TIGIT
Uniprot:	Q495A1
Entrez:	201633

Family

Belongs to:

No superfamily

Alternative Names

T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3; WUCAM

Molecular Weight

Mass (kDA):
26.319 kDA

Genomic Context


Human

Location:	3q13.31
Sequence:	3; NC_000003.12 (114291102..114329747)

Tissue Specificity

Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Autoimmune Diseases
Autoimmune Reaction
Neoplasms
Autoimmunity
Tissue Adhesions
Sclerosis
Chronic Infectious Disease
Hepatitis
Hepatitis C, Chronic
Multiple Sclerosis
Autoimmune Diseases Of The Nervous System
Hepatitis C

Experimental Autoimmune Encephalomyelitis
Virus Diseases
Delayed Hypersensitivity
Malignant Neoplasms
Nervousness
Viremia

Interacting Proteins

CD226
NECTIN2
NECTIN3
NECTIN4
PVR

Pathways

Cell Activation
Cell Proliferation
T Cell Activation
Immune Response
Cytokine Production
T Cell Proliferation
Cell Differentiation
Cell Adhesion
Cell-cell Signaling
Tissue Morphogenesis

Receptor Clustering
Hypersensitivity
Humoral Immune Response
Cell-cell Adhesion

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TIGIT

References

PMID: 19011627 by Yu X., et al. The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells.

PMID: 22421438 by Stengel K.F., et al. Structure of TIGIT immunoreceptor bound to poliovirus receptor reveals a cell-cell adhesion and signaling mechanism that requires cis-trans receptor clustering.