TGS1 Antibodies

AND TGS1 ELISA kits, TGS1 Proteins

Many biological assays use antibodies to detect TGS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with TGS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop TGS1 antibodies...

We validate the specificity of these antibodies to TGS1 by testing them on tissues known to express TGS1 positively and negatively. Browse below to find the TGS1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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TGS1 Infographic by Boster Bio

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TGS1 Overview

Facts about Trimethylguanosine synthase.

TGS1 3D structure. Source: alphafold

Trimethylguanosine synthase (TGS1)

Catalyzes the two serial methylation steps for the conversion of this 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation.

Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.

Gene Information

Human
Gene Name:	TGS1
Uniprot:	Q96RS0
Entrez:	96764

Family

Belongs to:

methyltransferase superfamily

Alternative Names

Cap-specific guanine-N2 methyltransferase; CLL-associated antigen KW-2; DKFZp762A163; EC 2.1.1; EC 2.1.1.-; HCA137; Hepatocellular carcinoma-associated antigen 137; NCOA6IPSEREX-defined; nuclear receptor coactivator 6 interacting protein; Nuclear receptor coactivator 6-interacting protein; PIMTFLJ22995; PIPMT; PRIP-interacting protein PIPMT; PRIP-interacting protein with methyltransferase domain; PRIP-interacting protein with methyltransferase motif; trimethylguanosine synthase 1; trimethylguanosine synthase homolog (S. cerevisiae); trimethylguanosine synthase homolog; trimethylguanosine synth

Molecular Weight

Mass (kDA):
96.62 kDA

Genomic Context


Human

Location:	8q12.1
Sequence:	8; NC_000008.11 (55773446..55826445)

Tissue Specificity

Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.

Subcellular Localizations

Cytoplasm. Nucleus, Cajal body. Nucleus, nucleolus. A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.

Diseases

Tuberculosis
Hypoxia
Anoxia
Granuloma
Abnormal Degeneration
Spinal Diseases
Anemia
Latent Tuberculosis
Neurodegenerative Disorders
Ataxia
Muscular Atrophy
Atrophy

Premature Aging Syndrome
Hypokinesia
Ataxia Telangiectasia
Malignant Neoplasms
Telangiectasis
Aplastic Anemia
Dyskeratosis Congenita

Interacting Proteins

FBL
NOP58

Pathways

Localization
Methylation
Transport
Nuclear Import
Translation
Cell Proliferation
Aging
Response To Hypoxia
Snorna Processing
Virulence
Nuclear Export
Cell Cycle Arrest

Ribosome Biogenesis
Cell Cycle
Wound Healing
Rna Processing
Meiosis
Rrna Processing

PTMs

Methylation

Phosphorylation

Cleavage

Research Areas

Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TGS1

References

PMID: 11517327 by Zhu Y.-J., et al. Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function.

PMID: 12200376 by Krackhardt A.M., et al. Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.