TGFBR3 Antibodies

Transforming growth factor beta receptor type 3 (TGFBR3)

Binds to TGF-beta.

Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.

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Gene Information

Human
Gene Name:	TGFBR3
Uniprot:	Q03167
Entrez:	7049

Family

Belongs to:
No superfamily

Alternative Names

betaglycan proteoglycan; Betaglycan; BGCAN; TBRIII; TGF-beta receptor type 3; TGF-beta receptor type III; TGF-beta RIII; TGFbetaRIII; TGFBR3; TGF-bRIII; TGFR-3; Transforming growth factor beta receptor III; transforming growth factor beta receptor type 3; transforming growth factor, beta receptor III (betaglycan, 300kDa); transforming growth factor, beta receptor III

Molecular Weight

Mass (kDA):
93.499 kDA

Genomic Context

Human
Location:	1p22.1
Sequence:	1; NC_000001.11 (91680343..91906002, complement)

Subcellular Localizations

Secreted. Secreted, extracellular space. Cell membrane; Single-pass type I membrane protein. Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Invasion
• Inflammation
• Sarcoma
• Malignant Neoplasm Of Lung
• Fracture
• Glaucoma
• Cholangiocarcinoma
• Anemia, Sickle Cell
• Tumor Angiogenesis
• Malignant Paraganglionic Neoplasm

• Prostatic Neoplasms
• Turner Syndrome
• Tissue Adhesions
• Ovarian Failure, Premature
• Neoplasm Invasiveness
• Non-small Cell Lung Carcinoma
• Soft Tissue Neoplasms

Interacting Proteins

• GIPC1
• TGFB1

Pathways

• Pathogenesis
• Cell Proliferation
• Immune Response
• Angiogenesis
• Cell Adhesion
• Lung Development
• Cell Differentiation
• Cognition
• Regulation Of Biological Process
• Cell Development
• Secretion
• Cell Migration

• Developmental Process
• Negative Regulation Of Cell Proliferation
• Ossification
• Cardiovascular System Development
• Vasculogenesis
• Biosynthetic Process
• Positive Regulation Of Cellular Process

PTMs

• Phosphorylation
• Methylation

• Reduction
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TGFBR3

Boster Bio Review - Best Uses Of The TGFBR3 Marker

In this Boster Bio review, we'll take a look at the Anti-TGF beta 1 and TGFBR3 markers and how they're used in research and application. This information applies to scientists worldwide. For more information, read on! After you've finished, you can decide whether or not Boster Bio is right for you. Whether you're a researcher or an entrepreneur, you can't go wrong with this anti-TGF beta 1 marker.

Boster Bio

Boster Bio's Anti-TGF Beta 1 TGFB1 Clone5D2 was produced with mouse ascites and affinity purified. It reacts with Human and is stable in storage at -20degC for one year or four degrees Celsius for one month. Available as a lyophilized anti-TGF beta 1 reagent, Boster Bio's TGF beta 1 antibody is stable at four degrees Celsius for one year or one month. The antibody comes in a vial with sodium chloride, trehalose, and Na2HPO4 to ensure that it is ready for use.

Anti-TGF beta 1

TGFBR3 is a gene whose expression is strongly associated with the presence of transforming growth factor beta (TGF-b). It is involved in cell transformation and is required for the progression of breast cancer. This marker is also involved in the regulation of Smad signaling. This study demonstrates that TbRIII inhibits MDA-MB231 cell invasion through Matrigel.

TGFBR3 plays a vital role in TGF-b signaling, and decreased expression in cancer cells may be associated with poorer prognosis. Its function in the tumor cell population appears to be closely related to its molecular form, with the transmembrane form enhancing the transduction of TGF-b, while the soluble form inhibits the signaling of TGF-b. It has also been shown that decreased TGFBR3 expression correlates with poor prognosis among patients.

The soluble form of betaglycan is an accessory receptor in the TGF-beta superfamily. It regulates TGF-beta actions via ligand-dependent interactions. The natural soluble form of betaglycan is found in serum and extracellular matrices and has potential as an anti-TGF-beta therapeutic agent. It is composed of two 110-kDa monomers that interact with one another non-covalently. In vertebrates, these soluble forms of betaglycan are modified with glycosaminoglycan chains.

The TGFBR3 protein binds to a variety of other members of the TGF-b family. Inhibin a-chain inhibits activin, whereas SB431542 inhibits TbRI and type I receptors of activin. Inhibin and activin are not involved in ccRCC cells, but TGFBR3 is. The protein has been implicated in TGF-b signaling, and may play a role in cell migration.

In vitro tests of human cancers have revealed that TGF-b inhibits the expression of several proteins including REG4. The results also suggest that TGF-b inhibits ALDh2A1 and reduces the tumor-initiating cell population. This mechanism could also be involved in the maintenance of CICs in many types of cancers. However, further study is needed to determine how TGFBR3 contributes to the tumor-initiating cells.

Besides being an important marker for the tumor-associated TGF-b protein, TbRIII also functions to suppress tumor invasion. By increasing its expression, TbRIII inhibits tumor growth by reducing tumor-inducing angiogenesis and invasiveness. The loss of TbRIII expression is a frequent step in the progression of breast cancer and increases the risk of metastasis.

TGFBR3 Marker

As a TGF-beta receptor, the Betaglycan is a cell surface proteoglycan with a molecular weight of 300 kDa. The receptor forms part of the cell membrane and often functions as a co-receptor with other TGF-beta receptor superfamily members. The receptor is often decreased in various cancers, and reduced expression has been reported. Currently, there are a number of tests and tools that use this marker.