TGF-beta receptor type-1 Antibodies

TGF-beta receptor type-1 (TGFBR1)

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Gene Information

Human
Gene Name:	TGFBR1
Uniprot:	P36897
Entrez:	7046

Family

Belongs to:
protein kinase superfamily

Alternative Names

AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; Activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK-5ALK5; EC 2.7.11; EC 2.7.11.30; LDS1A; LDS2A; Serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TGFB1R1; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta RI; TGF-beta type I receptor; TGFbetaRI; TGFBR1; TGF-bRI; TGFR-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-likekinase, 53kD); Transforming growth factor

Molecular Weight

Mass (kDA):
55.96 kDA

Genomic Context

Human
Location:	9q22.33
Sequence:	9; NC_000009.12 (99104038..99154192)

Tissue Specificity

Found in all tissues examined, most abundant in placenta and least abundant in brain and heart. Expressed in a variety of cancer cell lines (PubMed:25893292).

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Cell surface. Membrane raft.

Diseases

• Malignant Neoplasms
• Neoplasms
• Marfan Syndrome
• Aneurysm
• Loeys-dietz Syndrome
• Aortic Aneurysm
• Aortic Aneurysm, Thoracic
• Colorectal Cancer
• Carcinoma
• Connective Tissue Diseases
• Cleft Palate
• Colorectal Neoplasms
• Malignant Neoplasm Of Breast

• Mammary Neoplasms
• Orbital Separation Excessive
• Pathological Dilatation
• Dissecting Aortic Aneurysm
• Cell Transformation, Neoplastic
• Cleft Uvula
• Adenocarcinoma

Interacting Proteins

• FKBP1A
• LRG1
• TGFB1
• YWHAZ

Pathways

• Pathogenesis
• Cell Proliferation
• Secretion
• Localization
• Cell Growth
• Methylation
• Ovulation
• Cell Cycle
• Angiogenesis
• Cell Migration
• Oncogenesis
• Dna Methylation
• Regeneration

• Wound Healing
• Bone Resorption
• Rna Interference
• Cell Adhesion
• Developmental Process
• Lung Development
• Vasculogenesis

PTMs

• Phosphorylation
• Methylation

• Cleavage
• Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/TGFBR1

Best Uses Of The TGFBR1 Marker

The TGFBR1 gene gives instructions for the transforming growth factor beta receptor type 1 or TGFBR1 receptor. This receptor transmits signals from the cell's surface to the cell. Signal transduction is the process of transmitting signals and is essential because the environment around a cell can influence the functions of that cell. Researchers can utilize the TGFBR1 marker to understand how these molecules impact cell division and growth.

Specific

The TGFBR1 marker can be utilized for a variety purposes, including detection of tumor cells, assessment of the severity of cell injury, as well as analysis of the growth of cancer-cells. Although it is highly unlikely that the mutation was caused by DNA damage the protein is highly mutable. To determine the relation between the number of mutations and the probability of developing malignancy, a study using a case-control is required.

There are a variety of methods to identify TGFBR1 proteins. First, a stable transfected cell line was created at 5 x 10103 cells per well. TGFb1 was added for 96 hrs. After 48 hours, cells were removed and incubated in MTT (Methylthiazol-2-yl) bromide tetrazolium (1 mg/ml). The crystals were dispersed in DMSO/ethanol (1 to 1) and transferred onto 96-well plates. The results were analysed using an ELISA plate reader.

The Mouse TGF-b1 PicoKine(tm) ELISA kit was used to test the TGF-b1 levels in mouse cells. The cells were transfected with variant genes of MMP20 which were expressed in the R1B cells. After transfection, cells were then incubated for 60 minutes at 37°C with the antigen. The samples were then washed with PBS five times after which was added of 90 ul of TMB color-developing solution. Then, 100 uls stop solution was added. The samples were then read with a Synerby microplate reader H2.

Clinical

TGFBR1 is an octopoid cytokine that is involved in a myriad of cellular functions. It binds to the TGFBR1 receptor and invites TGFBR1 into the cell. It also activates downstream molecules, such as Runx2. TGFBR1 and its downstream protein PDI are significant elements in activating NFKB via the TNF receptor-associated factor 6 pathway.

TGFBR1 (miR-135a-5p) and TGFBR1 (miR-135a-5p) are TGF-b's molecular targets. The miR-135a-5p mimic inhibits TGFBR1 expression by targeting the miR-b pathway. Both RNAhybird and TargetScan have been tested to confirm their roles in TGFBR1 signaling. Inhibitors of miR-135a-5p have been found to decrease TGFBR1 expression in TGF-b1-cultured HASMCs.

TGF-b1 also induces Txndc5 expression in fibroblasts. TGFBR1 as well as Txndc5 are involved in the process of renal fibrosis. Txndc5 regulates ER stress levels and the activity of fibroblasts. TXNDC5 is a method to determine kidney fibrosis. It can also assist in the treatment.

In addition to the TGFBR1 marker TGF-b signals play an important role in the regulation of inflammation responses. Studies have demonstrated that TGFBR1 silencing can reduce the expression of TNF-a as well as NF-kB, which are linked to the calcification of the vascular system. These findings suggest that TGFBR1 could be decreased in CKD patients.

Molecule

The molecular functions of the TGFBR1 gene have been identified for various cancers. This gene could be an oncogene that regulates the cell pathway. This gene may be targeted to treat diseases. We have identified TGFBR1*6A as one of the new markers. This marker is highly specific and can aid in the selection of drugs for cancer. This article discusses the molecular applications of TGFBR1 gene markers.

The molecular applications of TGFBR1 gene markers are mostly limited to identifying genes that are associated with cancer. A recent study has revealed that the TGFBR1 marker could be used to diagnose lung cancer. The TGFBR1 gene regulates the expression of cancer-related genes. Scientists can determine the severity of cancer in a tumor by analysing TGFBR1 expression.

Using TGFBR1 as an indicator of tumors is a promising way to identify tumors that have aggressive growth patterns. The TGFBR1 gene marker has multiple molecular functions. These include studies on lung cancer, colon and Melanoma. Researchers also discovered that TGF-b induces TGFBR1 by increasing the stress on the ER and the ATF6-mediated transcriptional control.

The TGFBR1 gene gives instructions to make the TGFBR1 receptor. This receptor transmits signals from the cell's surface to the cell. This process is known as signal transduction. The signals control the activities of cells like growth or division. It also regulates cell metabolism. These genes are connected to numerous cancer-related research studies. However, they differ in a variety of ways. Researchers need to understand the function of TGFBR1 in the human body in order to appreciate their differences.

Cellular

TGFBR1 is an expression gene that encodes instructions for transforming growth factors beta receptor type 1 (TGFBR1) A cell molecule that transmits signals from cells' outer surroundings to its innermost parts. Cells use this molecule to regulate a variety of their behavior, including growth and division. Cellular uses of TGFBR1 have been investigated in a variety of cancers, as well as other diseases.

Cancer has been associated with an increase in TGFBR1 expression through the Kinase domain TFAP2C. TGFBR1 is a crucial chemical in oncogenic signaling and increased expression of this protein in cancer cells is a key factor in the growth of tumors. The gene is present in all tissues, including cancer cells. The TGFBR1 gene product has multiple roles in cancer. It has been implicated in the development of multiple types of tumors, such as breast, lung, pancreatic, and prostate cancer.

This gene family contains a variety of important proteins. Williamson JA, Vogelmann R. discovered the human homologues to the TGFBR1 marker. TGF-b1 can also be found in bone marrow. Its role in the study of cancer is well-understood. It could aid in determining the response of tumor cells to different medications. The potential to assist with the research into cancer is growing. We will gain a better understanding of the role of TGF-B cancer growth when we can enhance the expression of TGF-1 in cancer cells.

Generic

Instructions for the transforming growth factors beta receptor type 1 are provided by the TGFBR1 gene. Signal transduction is the process by which the TGFBR1 receptor transmits signals inside cells. The signals that are transmitted by the TGFBR1 receptor influence the activities of the cells, including its growth and division. This marker is used for measuring the TGF-1b1 level.

The TGF-b1 marker was used to measure the expression levels of BMPR2 and ETS1 in 786-O cells. TGF-b1 increases the expression of BMPR2 and ETS1 in these cell lines. The TGF-b1-related marker has numerous applications in the research field. It can also be used to examine the effects of TGF-1b1 on the immune system.

The gene TGF-b1 is also involved in the regulation of miRNAs. Exiqon (Qiagen GmbH) has reported that treatment with TGF-1 reduces the expression miRNAs. The researchers determined a threshold of detection as the 25th percentile of the overall image's signal intensity. Table SI contains all microarray analysis results.

Biological

The TGFBR1 gene contains instructions for transforming growth factor beta receptor type 1. The TGFBR1 receptor is responsible for transmitting signals from the cell surface into the cell. This process is called signal transduction and it determines how cells respond to environmental conditions that affect their growth and division. Boster Bio offers antibodies that react with TGFBR1 from humans.